Seroatlas · Human Serome Atlas

SEC61G

Protein transport protein Sec61 subunit gamma

Also known as: SC61G_HUMAN, SSS1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P60059
Gene: SEC61G
Ensembl: ENSG00000132432
Chromosome: 7
Canonical length: 68 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the gamma-subunit protein. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

68 residues, UniProt reviewed canonical sequence.

>P60059|SEC61G
     1  MDQVMQFVEP SRQFVKDSIR LVKRCTKPDR KEFQKIAMAT AIGFAIMGFI GFFVKLIHIP
    61  INNIIVGG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SEC61G can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 328 nTPM

Expression across tissuesHPA

Tissue

pancreas: 328 nTPM
epididymis: 323 nTPM
pituitary gland: 265 nTPM
blood vessel: 221 nTPM
liver: 221 nTPM
heart muscle: 207 nTPM

Single-cell type

gastric progenitor cells: 1,930 nCPM
esophageal apical cells: 1,339 nCPM
parietal cells: 1,124 nCPM
extravillous trophoblasts: 1,051 nCPM
epididymal principal cells: 1,047 nCPM
gastric chief cells: 1,047 nCPM

Immune cell

plasmacytoid DC: 699 nTPM
basophil: 297 nTPM
MAIT T-cell: 202 nTPM
T-reg: 169 nTPM
memory CD4 T-cell: 167 nTPM
non-classical monocyte: 157 nTPM

Brain region

choroid plexus: 59 nTPM
hypothalamus: 48 nTPM
white matter: 43 nTPM
cerebellum: 40 nTPM
thalamus: 38 nTPM
spinal cord: 37 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.93
gnomAD pLI: 0.63
gnomAD missense Z: 1.26
DepMap mean gene effect: -1.21
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

cytosol
membrane
Sec61 translocon complex
Ssh1 translocon complex

Protein domainsUniProt · Pfam · InterPro

Protein translocase complex, SecE/Sec61-gamma subunit
Protein translocase SEC61 complex, gamma subunit
Protein translocase SecE domain superfamily
SecE/Sec61-gamma subunits of protein translocation complex

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SEC61G as an antibody target. Whether an autoantibody or antibody against SEC61G could matter depends on whether native SEC61G is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SEC61G is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SEC61G as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...