SEC22A
Vesicle-trafficking protein SEC22a
Also known as: SC22A_HUMAN, SEC22L2
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96IW7
- Gene
- SEC22A
- Ensembl
- ENSG00000121542
- Chromosome
- 3
- Canonical length
- 307 aa
- Protein class
- Predicted intracellular proteins, Predicted membrane proteins
- Subcellular location
- Golgi apparatus,Vesicles
OverviewNCBI Gene
The protein encoded by this gene belongs to the member of the SEC22 family of vesicle trafficking proteins. This protein has similarity to rat SEC22 and may act in the early stages of the secretory pathway. [provided by RefSeq, Nov 2008]
Canonical amino-acid sequenceUniProt
307 residues, UniProt reviewed canonical sequence.
>Q96IW7|SEC22A
1 MSMILSASVI RVRDGLPLSA STDYEQSTGM QECRKYFKML SRKLAQLPDR CTLKTGHYNI
61 NFISSLGVSY MMLCTENYPN VLAFSFLDEL QKEFITTYNM MKTNTAVRPY CFIEFDNFIQ
121 RTKQRYNNPR SLSTKINLSD MQTEIKLRPP YQISMCELGS ANGVTSAFSV DCKGAGKISS
181 AHQRLEPATL SGIVGFILSL LCGALNLIRG FHAIESLLQS DGDDFNYIIA FFLGTAACLY
241 QCYLLVYYTG WRNVKSFLTF GLICLCNMYL YELRNLWQLF FHVTVGAFVT LQIWLRQAQG
301 KAPDYDVLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SEC22A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 4
- Mean surface accessibility (rSASA)
- 0.33
- Highest tissue expression
- 20 nTPM
Expression across tissuesHPA
Tissue
- testis: 20 nTPM
- tonsil: 12 nTPM
- liver: 12 nTPM
- skin: 12 nTPM
- ovary: 11 nTPM
- smooth muscle: 11 nTPM
Single-cell type
- somatotrophs: 153 nCPM
- microglia: 151 nCPM
- lactotrophs: 142 nCPM
- sertoli cells: 141 nCPM
- early primary spermatocytes: 140 nCPM
- thyrotrophs: 138 nCPM
Immune cell
- MAIT T-cell: 30 nTPM
- NK-cell: 29 nTPM
- T-reg: 28 nTPM
- memory CD8 T-cell: 26 nTPM
- naive CD4 T-cell: 26 nTPM
- memory CD4 T-cell: 25 nTPM
Brain region
- cerebellum: 18 nTPM
- white matter: 16 nTPM
- hippocampal formation: 15 nTPM
- pons: 15 nTPM
- midbrain: 14 nTPM
- hypothalamus: 14 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.2
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.08
- DepMap mean gene effect
- -0.08
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SEC22A as an antibody target. Whether an autoantibody or antibody against SEC22A could matter depends on whether native SEC22A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SEC22A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SEC22A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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