SEC14L6
SEC14-like protein 6
Also known as: S14L6_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- B5MCN3
- Gene
- SEC14L6
- Ensembl
- ENSG00000214491
- Chromosome
- 22
- Canonical length
- 397 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
397 residues, UniProt reviewed canonical sequence.
>B5MCN3|SEC14L6
1 MSGQVGDLSP SQEKSLAQFR ENIQDVLSAL PNPDDYFLLR WLQARSFDLQ KSEDMLRKHM
61 EFRKQQDLAN ILAWQPPEVV RLYNANGICG HDGEGSPVWY HIVGSLDPKG LLLSASKQEL
121 LRDSFRSCEL LLRECELQSQ KLGKRVEKII AIFGLEGLGL RDLWKPGIEL LQEFFSALEA
181 NYPEILKSLI VVRAPKLFAV AFNLVKSYMS EETRRKVVIL GDNWKQELTK FISPDQLPVE
241 FGGTMTDPDG NPKCLTKINY GGEVPKSYYL CKQVRLQYEH TRSVGRGSSL QVENEILFPG
301 CVLRWQFASD GGDIGFGVFL KTKMGERQRA REMTEVLPSQ RYNAHMVPED GILTCLQAGS
361 YVLRFYNTYS LVHSKRISYT VEVLLPDQTF MEKMEKFLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SEC14L6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.25
- Highest tissue expression
- 20 nTPM
Expression across tissuesHPA
Tissue
- parathyroid gland: 20 nTPM
- epididymis: 14 nTPM
- lung: 7.5 nTPM
- kidney: 5 nTPM
- choroid plexus: 4.8 nTPM
- skin: 4.4 nTPM
Single-cell type
- sertoli cells: 43 nCPM
- müller glia: 31 nCPM
- loop of henle epithelial cells: 21 nCPM
- epididymal principal cells: 17 nCPM
- distal convoluted tubule cells: 17 nCPM
- transitional alveolar cells: 16 nCPM
Immune cell
- basophil: 0.6 nTPM
- neutrophil: 0.5 nTPM
- T-reg: 0.4 nTPM
- NK-cell: 0.3 nTPM
- classical monocyte: 0.2 nTPM
- MAIT T-cell: 0.2 nTPM
Brain region
- pons: 16 nTPM
- thalamus: 15 nTPM
- medulla oblongata: 13 nTPM
- choroid plexus: 12 nTPM
- midbrain: 11 nTPM
- amygdala: 10 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.06
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.28
- DepMap mean gene effect
- 0.11
- DepMap dependency class
- selective
OntologyGO
Cellular components
Protein domainsUniProt · Pfam · InterPro
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SEC14L6 as an antibody target. Whether an autoantibody or antibody against SEC14L6 could matter depends on whether native SEC14L6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SEC14L6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SEC14L6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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