Seroatlas · Human Serome Atlas

SEC14L5

SEC14-like protein 5

Also known as: KIAA0420, PRELID4B, S14L5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O43304
Gene: SEC14L5
Ensembl: ENSG00000103184
Chromosome: 16
Canonical length: 696 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus,Cytosol

OverviewNCBI Gene

Predicted to be located in mitochondrial intermembrane space. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

696 residues, UniProt reviewed canonical sequence.

>O43304|SEC14L5
     1  MVQRYQSPVR VYKYPFELVM AAYEKRFPTC PQIPVFLGSE VLRESRSPDG AVHVVERSCR
    61  LRVDAPRLLR KIAGVEHVVF VQTNILNWKE RTLLIEAHNE TFANRVVVNE HCSYTVHPEN
   121  EDWTCFEQSA SLDIRSFFGF ENALEKIAMK QYTANVKRGK EVIEHYLNEL ISQGTSHIPR
   181  WTPAPVREED ARNQAGPRDP SSLEAHGPRS TLGPALEAVS MDGDKLDADY IERCLGHLTP
   241  MQESCLIQLR HWLQETHKGK IPKDEHILRF LRAHDFHLDK AREMLRQSLS WRKQHQVDLL
   301  LQTWQPPALL EEFYAGGWHY QDIDGRPLYI LRLGQMDTKG LMKAVGEEAL LRHVLSVNEE
   361  GQKRCEGSTR QLGRPISSWT CLLDLEGLNM RHLWRPGVKA LLRMIEVVED NYPETLGRLL
   421  IVRAPRVFPV LWTLISPFIN ENTRRKFLIY SGSNYQGPGG LVDYLDREVI PDFLGGESVC
   481  NVPEGGLVPK SLYMTEEEQE HTDQLWQWSE TYHSASVLRG APHEVAVEIL EGESVITWDF
   541  DILRGDVVFS LYHTKQAPRL GAREPGTRAS GQLIDKGWVL GRDYSRVEAP LVCREGESIQ
   601  GSHVTRWPGV YLLQWQMHSP PSSVACSLPG VDDVLTALHS PGPKCKLLYY CEVLASEDFR
   661  GSMSSLESCT SGFSQLSAAT SSSSSGQSHS SSLVSR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SEC14L5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 35 nTPM
midbrain: 19 nTPM
basal ganglia: 18 nTPM
cerebral cortex: 17 nTPM
hippocampal formation: 17 nTPM
tongue: 10 nTPM

Single-cell type

cone photoreceptor cells: 186 nCPM
oligodendrocytes: 149 nCPM
gonadotrophs: 34 nCPM
brain excitatory neurons: 32 nCPM
brain inhibitory neurons: 25 nCPM
myonuclei: 21 nCPM

Immune cell

total PBMC: 0.6 nTPM
neutrophil: 0.2 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

white matter: 173 nTPM
basal ganglia: 105 nTPM
midbrain: 90 nTPM
medulla oblongata: 85 nTPM
cerebral cortex: 84 nTPM
thalamus: 80 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.25
gnomAD pLI: 0
gnomAD missense Z: -1.43
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SEC14L5 as an antibody target. Whether an autoantibody or antibody against SEC14L5 could matter depends on whether native SEC14L5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SEC14L5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SEC14L5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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