Seroatlas · Human Serome Atlas

SEC14L4

SEC14-like protein 4

Also known as: dJ130H16.5, S14L4_HUMAN, TAP3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UDX3
Gene: SEC14L4
Ensembl: ENSG00000133488
Chromosome: 22
Canonical length: 406 aa
Protein class: Predicted intracellular proteins, Transporters
Subcellular location: Vesicles,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is highly similar to the protein encoded by the Saccharomyces cerevisiae SEC14 gene. The SEC14 protein is a phophatidylinositol transfer protein that is essential for biogenesis of Golgi-derived transport vesicles, and thus is required for the export of yeast secretory proteins from the Golgi complex. The specific function of this protein has not yet been determined. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2009]

Canonical amino-acid sequenceUniProt

406 residues, UniProt reviewed canonical sequence.

>Q9UDX3|SEC14L4
     1  MSSRVGDLSP QQQEALARFR ENLQDLLPIL PNADDYFLLR WLRARNFDLQ KSEDMLRRHM
    61  EFRKQQDLDN IVTWQPPEVI QLYDSGGLCG YDYEGCPVYF NIIGSLDPKG LLLSASKQDM
   121  IRKRIKVCEL LLHECELQTQ KLGRKIEMAL MVFDMEGLSL KHLWKPAVEV YQQFFSILEA
   181  NYPETLKNLI VIRAPKLFPV AFNLVKSFMS EETRRKIVIL GDNWKQELTK FISPDQLPVE
   241  FGGTMTDPDG NPKCLTKINY GGEVPKSYYL CEQVRLQYEH TRSVGRGSSL QVENEILFPG
   301  CVLRWQFASD GGDIGFGVFL KTKMGEQQSA REMTEVLPSQ RYNAHMVPED GSLTCLQAGV
   361  YVLRFDNTYS RMHAKKLSYT VEVLLPDKAS EETLQSLKAM RPSPTQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SEC14L4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

liver: 18 nTPM
bone marrow: 7.7 nTPM
testis: 4.3 nTPM
lung: 4.2 nTPM
parathyroid gland: 3.1 nTPM
adrenal gland: 0.8 nTPM

Single-cell type

sertoli cells: 51 nCPM
hepatocytes: 39 nCPM
respiratory ciliated cells: 39 nCPM
erythrocyte progenitors: 26 nCPM
cholangiocytes: 16 nCPM
müller glia: 9.2 nCPM

Immune cell

basophil: 0.7 nTPM
neutrophil: 0.2 nTPM
naive B-cell: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

white matter: 2.1 nTPM
cerebral cortex: 1.7 nTPM
medulla oblongata: 1.7 nTPM
thalamus: 1.7 nTPM
cerebellum: 1.6 nTPM
midbrain: 1.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.13
gnomAD pLI: 0
gnomAD missense Z: 0.27
DepMap mean gene effect: -0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

lipid binding

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SEC14L4 as an antibody target. Whether an autoantibody or antibody against SEC14L4 could matter depends on whether native SEC14L4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SEC14L4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SEC14L4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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