Seroatlas · Human Serome Atlas

SEC14L3

SEC14-like protein 3

Also known as: S14L3_HUMAN, TAP2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UDX4
Gene: SEC14L3
Ensembl: ENSG00000100012
Chromosome: 22
Canonical length: 400 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene is highly similar to the protein encoded by the Saccharomyces cerevisiae SEC14 gene. The SEC14 protein is a phophatidylinositol transfer protein that is essential for biogenesis of Golgi-derived transport vesicles, and thus is required for the export of yeast secretory proteins from the Golgi complex. The specific function of this protein has not yet been determined. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

Canonical amino-acid sequenceUniProt

400 residues, UniProt reviewed canonical sequence.

>Q9UDX4|SEC14L3
     1  MSGRVGDLSP KQAETLAKFR ENVQDVLPAL PNPDDYFLLR WLRARNFDLQ KSEALLRKYM
    61  EFRKTMDIDH ILDWQPPEVI QKYMPGGLCG YDRDGCPVWY DIIGPLDPKG LLFSVTKQDL
   121  LKTKMRDCER ILHECDLQTE RLGKKIETIV MIFDCEGLGL KHFWKPLVEV YQEFFGLLEE
   181  NYPETLKFML IVKATKLFPV GYNLMKPFLS EDTRRKIIVL GNNWKEGLLK LISPEELPAQ
   241  FGGTLTDPDG NPKCLTKINY GGEIPKSMYV RDQVKTQYEH SVQINRGSSH QVEYEILFPG
   301  CVLRWQFSSD GADIGFGVFL KTKMGERQRA GEMTDVLPSQ RYNAHMVPED GNLTCSEAGV
   361  YVLRFDNTYS FVHAKKVSFT VEVLLPDEGM QKYDKELTPV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SEC14L3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 8.4 nTPM

Expression across tissuesHPA

Tissue

retina: 8.4 nTPM
bone marrow: 3.6 nTPM
liver: 2.7 nTPM
thyroid gland: 1.6 nTPM
lung: 1 nTPM
fallopian tube: 0.3 nTPM

Single-cell type

müller glia: 105 nCPM
respiratory ciliated cells: 31 nCPM
erythrocyte progenitors: 17 nCPM
epicardial cells: 6.8 nCPM
respiratory secretory cells: 2.4 nCPM
erythrocytes: 2.2 nCPM

Immune cell

basophil: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 2.3 nTPM
cerebellum: 2.2 nTPM
cerebral cortex: 2.2 nTPM
pons: 2.1 nTPM
medulla oblongata: 2 nTPM
amygdala: 1.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.65
gnomAD pLI: 0
gnomAD missense Z: 0.26
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

lipid binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SEC14L3 as an antibody target. Whether an autoantibody or antibody against SEC14L3 could matter depends on whether native SEC14L3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SEC14L3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SEC14L3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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