Seroatlas · Human Serome Atlas

SEC14L2

SEC14-like protein 2

Also known as: C22orf6, KIAA1186, KIAA1658, S14L2_HUMAN, SPF, TAP, TAP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O76054
Gene
SEC14L2
Ensembl
ENSG00000100003
Chromosome
22
Canonical length
403 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a cytosolic protein which belongs to a family of lipid-binding proteins including Sec14p, alpha-tocopherol transfer protein, and cellular retinol-binding protein. The encoded protein stimulates squalene monooxygenase which is a downstream enzyme in the cholesterol biosynthetic pathway. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]

Canonical amino-acid sequenceUniProt

403 residues, UniProt reviewed canonical sequence.

>O76054|SEC14L2
     1  MSGRVGDLSP RQKEALAKFR ENVQDVLPAL PNPDDYFLLR WLRARSFDLQ KSEAMLRKHV
    61  EFRKQKDIDN IISWQPPEVI QQYLSGGMCG YDLDGCPVWY DIIGPLDAKG LLFSASKQDL
   121  LRTKMRECEL LLQECAHQTT KLGRKVETIT IIYDCEGLGL KHLWKPAVEA YGEFLCMFEE
   181  NYPETLKRLF VVKAPKLFPV AYNLIKPFLS EDTRKKIMVL GANWKEVLLK HISPDQVPVE
   241  YGGTMTDPDG NPKCKSKINY GGDIPRKYYV RDQVKQQYEH SVQISRGSSH QVEYEILFPG
   301  CVLRWQFMSD GADVGFGIFL KTKMGERQRA GEMTEVLPNQ RYNSHLVPED GTLTCSDPGI
   361  YVLRFDNTYS FIHAKKVNFT VEVLLPDKAS EEKMKQLGAG TPK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SEC14L2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
228 nTPM

Expression across tissuesHPA

Tissue

  • liver: 228 nTPM
  • epididymis: 81 nTPM
  • retina: 60 nTPM
  • prostate: 49 nTPM
  • choroid plexus: 46 nTPM
  • breast: 42 nTPM

Single-cell type

  • müller glia: 89 nCPM
  • astrocytes: 68 nCPM
  • rod photoreceptor cells: 58 nCPM
  • hepatocytes: 55 nCPM
  • retinal pigment epithelial cells: 55 nCPM
  • esophageal apical cells: 53 nCPM

Immune cell

  • naive CD4 T-cell: 3.8 nTPM
  • naive CD8 T-cell: 2.7 nTPM
  • memory CD4 T-cell: 1.4 nTPM
  • total PBMC: 0.8 nTPM
  • T-reg: 0.7 nTPM
  • gdT-cell: 0.5 nTPM

Brain region

  • medulla oblongata: 79 nTPM
  • basal ganglia: 73 nTPM
  • thalamus: 71 nTPM
  • hypothalamus: 66 nTPM
  • midbrain: 65 nTPM
  • cerebral cortex: 60 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SEC14L2.

Disease | ImmuneIEDB

Conditions an epitope on SEC14L2 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.94
gnomAD pLI
0
gnomAD missense Z
0.99
DepMap mean gene effect
-0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SEC14L2 as an antibody target. Whether an autoantibody or antibody against SEC14L2 could matter depends on whether native SEC14L2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SEC14L2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SEC14L2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SEC14L2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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