Seroatlas · Human Serome Atlas

SEBOX

Homeobox protein SEBOX

Also known as: OG9, OG9X, SEBOX_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HB31
Gene: SEBOX
Ensembl: ENSG00000274529
Chromosome: 17
Canonical length: 190 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Homeodomain proteins, such as SEBOX, play a key role in coordinating gene expression during development (Cinquanta et al., 2000 [PubMed 10922053]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

190 residues, UniProt reviewed canonical sequence.

>Q9HB31|SEBOX
     1  MPSPVDASSA DGGSGLGSHR RKRTTFSKGQ LLELERAFAA WPYPNISTHE HLAWVTCLPE
    61  AKVQVWFQKR WAKIIKNRKS GILSPGSECP QSSCSLPDTL QQPWDPQMPG QPPPSSGTPQ
   121  RTSVCRHSSC PAPGLSPRQG WEGAKAVAPW GSAGASEVHP SLERATPQTS LGSLSDLIYA
   181  LAIVVNVDHS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SEBOX can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 1.1 nTPM

Expression across tissuesHPA

Tissue

liver: 1.1 nTPM
testis: 0.3 nTPM
retina: 0.2 nTPM
cerebellum: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM

Single-cell type

late spermatids: 8.1 nCPM
early spermatids: 6.2 nCPM
cone photoreceptor cells: 2.1 nCPM
retinal horizontal cells: 2 nCPM
late primary spermatocytes: 0.5 nCPM
cardiomyocytes: 0.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 3.2 nTPM
cerebral cortex: 2.5 nTPM
white matter: 2.5 nTPM
hypothalamus: 2.3 nTPM
hippocampal formation: 2.2 nTPM
amygdala: 2.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SEBOX as an antibody target. Whether an autoantibody or antibody against SEBOX could matter depends on whether native SEBOX is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SEBOX is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SEBOX as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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