SDSL
Serine dehydratase-like
Also known as: cSDH, SDS-RS1, SDSL_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96GA7
- Gene
- SDSL
- Ensembl
- ENSG00000139410
- Chromosome
- 12
- Canonical length
- 329 aa
- Protein class
- Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
- Subcellular location
- Cytosol
- Quaternary structure
- Homodimer
OverviewNCBI Gene
Enables L-serine ammonia-lyase activity; identical protein binding activity; and threonine deaminase activity. Predicted to be involved in L-serine catabolic process. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
329 residues, UniProt reviewed canonical sequence.
>Q96GA7|SDSL
1 MDGPVAEHAK QEPFHVVTPL LESWALSQVA GMPVFLKCEN VQPSGSFKIR GIGHFCQEMA
61 KKGCRHLVCS SGGNAGIAAA YAARKLGIPA TIVLPESTSL QVVQRLQGEG AEVQLTGKVW
121 DEANLRAQEL AKRDGWENVP PFDHPLIWKG HASLVQELKA VLRTPPGALV LAVGGGGLLA
181 GVVAGLLEVG WQHVPIIAME THGAHCFNAA ITAGKLVTLP DITSVAKSLG AKTVAARALE
241 CMQVCKIHSE VVEDTEAVSA VQQLLDDERM LVEPACGAAL AAIYSGLLRR LQAEGCLPPS
301 LTSVVVIVCG GNNINSRELQ ALKTHLGQVLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SDSL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.22
- Highest tissue expression
- 102 nTPM
Expression across tissuesHPA
Tissue
- liver: 102 nTPM
- kidney: 35 nTPM
- adrenal gland: 32 nTPM
- thyroid gland: 24 nTPM
- midbrain: 21 nTPM
- spinal cord: 19 nTPM
Single-cell type
- hepatocytes: 122 nCPM
- hofbauer cells: 61 nCPM
- enterocytes: 58 nCPM
- colonocytes: 51 nCPM
- epididymal principal cells: 50 nCPM
- epididymal efferent duct absorptive cells: 44 nCPM
Immune cell
- myeloid DC: 19 nTPM
- plasmacytoid DC: 18 nTPM
- intermediate monocyte: 10 nTPM
- classical monocyte: 8.7 nTPM
- total PBMC: 2.5 nTPM
- memory B-cell: 2.2 nTPM
Brain region
- medulla oblongata: 23 nTPM
- white matter: 20 nTPM
- thalamus: 18 nTPM
- cerebellum: 18 nTPM
- midbrain: 18 nTPM
- pons: 18 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.81
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.07
- DepMap mean gene effect
- 0.08
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
- identical protein binding
- L-serine ammonia-lyase activity
- pyridoxal phosphate binding
- threonine deaminase activity
- glutamate racemase activity
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SDSL as an antibody target. Whether an autoantibody or antibody against SDSL could matter depends on whether native SDSL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SDSL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SDSL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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