Seroatlas · Human Serome Atlas

SDS

L-serine dehydratase/L-threonine deaminase

Also known as: SDH, SDHL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P20132
Gene: SDS
Ensembl: ENSG00000135094
Chromosome: 12
Canonical length: 328 aa
Protein class: Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location: Mitochondria,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes one of three enzymes that are involved in metabolizing serine and glycine. L-serine dehydratase converts L-serine to pyruvate and ammonia and requires pyridoxal phosphate as a cofactor. The encoded protein can also metabolize threonine to NH4+ and 2-ketobutyrate. The encoded protein is found predominantly in the liver. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

328 residues, UniProt reviewed canonical sequence.

>P20132|SDS
     1  MMSGEPLHVK TPIRDSMALS KMAGTSVYLK MDSAQPSGSF KIRGIGHFCK RWAKQGCAHF
    61  VCSSAGNAGM AAAYAARQLG VPATIVVPST TPALTIERLK NEGATVKVVG ELLDEAFELA
   121  KALAKNNPGW VYIPPFDDPL IWEGHASIVK ELKETLWEKP GAIALSVGGG GLLCGVVQGL
   181  QEVGWGDVPV IAMETFGAHS FHAATTAGKL VSLPKITSVA KALGVKTVGA QALKLFQEHP
   241  IFSEVISDQE AVAAIEKFVD DEKILVEPAC GAALAAVYSH VIQKLQLEGN LRTPLPSLVV
   301  IVCGGSNISL AQLRALKEQL GMTNRLPK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SDS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.23
Highest tissue expression: 972 nTPM

Expression across tissuesHPA

Tissue

liver: 972 nTPM
basal ganglia: 48 nTPM
midbrain: 32 nTPM
choroid plexus: 21 nTPM
hypothalamus: 20 nTPM
amygdala: 17 nTPM

Single-cell type

hepatocytes: 481 nCPM
macrophages: 156 nCPM
kupffer cells: 74 nCPM
monocytes: 73 nCPM
cdc: 54 nCPM
astrocytes: 41 nCPM

Immune cell

myeloid DC: 12 nTPM
plasmacytoid DC: 1.2 nTPM
classical monocyte: 0.7 nTPM
intermediate monocyte: 0.7 nTPM
neutrophil: 0.5 nTPM
total PBMC: 0.4 nTPM

Brain region

medulla oblongata: 50 nTPM
midbrain: 44 nTPM
thalamus: 28 nTPM
basal ganglia: 27 nTPM
pons: 20 nTPM
hypothalamus: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.07
gnomAD pLI: 0
gnomAD missense Z: 1.04
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SDS as an antibody target. Whether an autoantibody or antibody against SDS could matter depends on whether native SDS is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SDS is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SDS as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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