Seroatlas · Human Serome Atlas

SDHAF4

Succinate dehydrogenase assembly factor 4, mitochondrial

Also known as: C6orf57, Sdh8, SDHF4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VUM1
Gene: SDHAF4
Ensembl: ENSG00000154079
Chromosome: 6
Canonical length: 108 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Mitochondria

OverviewNCBI Gene

Predicted to enable enzyme activator activity. Involved in cellular respiration and mitochondrial respiratory chain complex II assembly. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

108 residues, UniProt reviewed canonical sequence.

>Q5VUM1|SDHAF4
     1  MTPSRLPWLL SWVSATAWRA ARSPLLCHSL RKTSSSQGGK SELVKQSLKK PKLPEGRFDA
    61  PEDSHLEKEP LEKFPDDVNP VTKEKGGPRG PEPTRYGDWE RKGRCIDF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SDHAF4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 22 nTPM
hypothalamus: 18 nTPM
cerebral cortex: 17 nTPM
basal ganglia: 16 nTPM
amygdala: 15 nTPM
hippocampal formation: 15 nTPM

Single-cell type

adipocytes: 39 nCPM
fallopian tube ciliated cells: 32 nCPM
medullary thymic epithelial cells: 26 nCPM
myonuclei: 26 nCPM
renal collecting duct principal cells: 26 nCPM
respiratory ciliated cells: 24 nCPM

Immune cell

plasmacytoid DC: 6.1 nTPM
myeloid DC: 5.1 nTPM
naive B-cell: 4.7 nTPM
NK-cell: 4.7 nTPM
classical monocyte: 4.6 nTPM
non-classical monocyte: 4.6 nTPM

Brain region

hypothalamus: 21 nTPM
cerebral cortex: 18 nTPM
basal ganglia: 17 nTPM
choroid plexus: 17 nTPM
white matter: 17 nTPM
pons: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.28
gnomAD pLI: 0.1
DepMap mean gene effect: 0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Succinate dehydrogenase assembly factor 4
Protein of unknown function (DUF1674)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SDHAF4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SDHA

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SDHAF4 as an antibody target. Whether an autoantibody or antibody against SDHAF4 could matter depends on whether native SDHAF4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SDHAF4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SDHAF4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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