Seroatlas · Human Serome Atlas

SDHAF3

Succinate dehydrogenase assembly factor 3, mitochondrial

Also known as: ACN9, DC11, LYRM10, Sdh7, SDHF3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NRP4
Gene
SDHAF3
Ensembl
ENSG00000196636
Chromosome
7
Canonical length
125 aa
Protein class
Predicted intracellular proteins
Subcellular location
Mitochondria

OverviewNCBI Gene

Predicted to be involved in mitochondrial respiratory chain complex II assembly; regulation of gluconeogenesis; and succinate metabolic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

125 residues, UniProt reviewed canonical sequence.

>Q9NRP4|SDHAF3
     1  MPGRHVSRVR ALYKRVLQLH RVLPPDLKSL GDQYVKDEFR RHKTVGSDEA QRFLQEWEVY
    61  ATALLQQANE NRQNSTGKAC FGTFLPEEKL NDFRDEQIGQ LQELMQEATK PNRQFSISES
   121  MKPKF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SDHAF3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
31 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 31 nTPM
  • liver: 30 nTPM
  • skeletal muscle: 27 nTPM
  • heart muscle: 25 nTPM
  • tongue: 24 nTPM
  • thymus: 23 nTPM

Single-cell type

  • megakaryocytes: 161 nCPM
  • late primary spermatocytes: 152 nCPM
  • early spermatids: 122 nCPM
  • oocytes: 120 nCPM
  • neutrophils: 104 nCPM
  • gastric progenitor cells: 104 nCPM

Immune cell

  • plasmacytoid DC: 83 nTPM
  • naive CD4 T-cell: 46 nTPM
  • naive CD8 T-cell: 45 nTPM
  • memory CD8 T-cell: 39 nTPM
  • total PBMC: 38 nTPM
  • MAIT T-cell: 36 nTPM

Brain region

  • choroid plexus: 17 nTPM
  • white matter: 14 nTPM
  • spinal cord: 13 nTPM
  • hypothalamus: 12 nTPM
  • medulla oblongata: 12 nTPM
  • cerebellum: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.72
gnomAD pLI
0
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SDHAF3 as an antibody target. Whether an autoantibody or antibody against SDHAF3 could matter depends on whether native SDHAF3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SDHAF3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SDHAF3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SDHAF3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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