Seroatlas · Human Serome Atlas

SCYGR6

Small cysteine and glycine repeat-containing protein 6

Also known as: KRTAP28-6, SCGR6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A286YF77
Gene
SCYGR6
Ensembl
ENSG00000284725
Chromosome
2
Canonical length
105 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be located in intermediate filament. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

105 residues, UniProt reviewed canonical sequence.

>A0A286YF77|SCYGR6
     1  MGCCGCGGCG GGCGGCGGGC SGGCGGGCGG GCGSCTTCRC YRVGCCSSCC PCCRGCCGGC
    61  CSTPVICCCR RTCHSCGCGC GCGKGCCQQK GCCQQKGCCK KQCCC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SCYGR6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.59
Highest tissue expression
3.9 nTPM

Expression across tissuesHPA

Tissue

  • skin: 3.9 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM
  • basal ganglia: 0 nTPM

Single-cell type

  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM
  • astrocytes: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • medulla oblongata: 0.8 nTPM
  • pons: 0.1 nTPM
  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM

OntologyGO

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SCYGR6 as an antibody target. Whether an autoantibody or antibody against SCYGR6 could matter depends on whether native SCYGR6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SCYGR6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SCYGR6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SCYGR6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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