Seroatlas · Human Serome Atlas

SCYGR4

Small cysteine and glycine repeat-containing protein 4

Also known as: KRTAP28-4, SCGR4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A286YEV6
Gene
SCYGR4
Ensembl
ENSG00000284631
Chromosome
2
Canonical length
105 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be located in intermediate filament. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

105 residues, UniProt reviewed canonical sequence.

>A0A286YEV6|SCYGR4
     1  MGCCGCGSCG GCGGRCGGGC GGGCSGGCGG GCGGGCGGGC GSCTTCRCYR VGCCSSCCPC
    61  CRGCCGGCCS TPVICCCRRT CGSCGCGYGK GCCQQKCCCQ KQCCC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SCYGR4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.59
Highest tissue expression
8 nTPM

Expression across tissuesHPA

Tissue

  • placenta: 8 nTPM
  • skin: 1.8 nTPM
  • testis: 1.4 nTPM
  • midbrain: 1.3 nTPM
  • spinal cord: 1.3 nTPM
  • basal ganglia: 1.2 nTPM

Single-cell type

  • platelets: 7 nCPM
  • other brain neurons: 0.7 nCPM
  • distal convoluted tubule cells: 0.1 nCPM
  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM

Immune cell

  • total PBMC: 0.2 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • amygdala: 4.3 nTPM
  • medulla oblongata: 4.2 nTPM
  • thalamus: 4.2 nTPM
  • pons: 3.6 nTPM
  • basal ganglia: 3 nTPM
  • cerebral cortex: 2.9 nTPM

OntologyGO

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SCYGR4 as an antibody target. Whether an autoantibody or antibody against SCYGR4 could matter depends on whether native SCYGR4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SCYGR4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SCYGR4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SCYGR4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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