Seroatlas · Human Serome Atlas

SCYGR2

Small cysteine and glycine repeat-containing protein 2

Also known as: KRTAP28-2, SCGR2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A286YFB4
Gene
SCYGR2
Ensembl
ENSG00000284643
Chromosome
2
Canonical length
120 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be located in intermediate filament. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

120 residues, UniProt reviewed canonical sequence.

>A0A286YFB4|SCYGR2
     1  MGCCGCGGCG GCGGRCGGCG GGCGGGCGGG CGGGCGGGCG GGCGGGCGGG CGGSCGSCTT
    61  CRCYRVGCCS SCCPCCRGCC GGCCSTPVIC CCRRTCHSCG CGCGKGCCQQ KCCCQKQCCC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SCYGR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.61
Highest tissue expression
1.6 nTPM

Expression across tissuesHPA

Tissue

  • skin: 1.6 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM
  • basal ganglia: 0 nTPM

Single-cell type

  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM
  • astrocytes: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • white matter: 0.8 nTPM
  • cerebral cortex: 0.6 nTPM
  • hypothalamus: 0.5 nTPM
  • thalamus: 0.5 nTPM
  • hippocampal formation: 0.4 nTPM
  • pons: 0.3 nTPM

OntologyGO

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SCYGR2 as an antibody target. Whether an autoantibody or antibody against SCYGR2 could matter depends on whether native SCYGR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SCYGR2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SCYGR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SCYGR2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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