Seroatlas · Human Serome Atlas

SCYGR10

Small cysteine and glycine repeat-containing protein 10

Also known as: KRTAP28-10, KRTAP28p2, SCGRX_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A286YEX9
Gene
SCYGR10
Ensembl
ENSG00000284622
Chromosome
2
Canonical length
105 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

This gene is a member of a large gene family that encodes keratin associated proteins (KRTAP) that play a role in hair formation. This gene belongs to a subfamily of the KRTAP family termed small cysteine and glycine repeat containing (SCYGR) genes and it resides in a cluster of SCYGR genes on chromosome 2q36.3. Allelic polymorphisms in this gene result in both coding and non-coding transcripts; the reference genome represents the non-coding allele. [provided by RefSeq, Jan 2024]

Canonical amino-acid sequenceUniProt

105 residues, UniProt reviewed canonical sequence.

>A0A286YEX9|SCYGR10
     1  MGCCGCGGCG GRCSGGCGGG CGGGCGGGCG GGCGGCGGGC GSYTTCRYYR VGCCSSCCPC
    61  CRGCCGGCCS TPVICCCRRT CRSCGCGCGK SCCQQKCCCQ KQCCC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SCYGR10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.62
Highest tissue expression
0.1 nTPM

Expression across tissuesHPA

Tissue

  • retina: 0.1 nTPM
  • testis: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • appendix: 0 nTPM
  • bone marrow: 0 nTPM

Single-cell type

  • cdc: 0.1 nCPM
  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 1.4 nTPM
  • thalamus: 1.2 nTPM
  • basal ganglia: 0.6 nTPM
  • hippocampal formation: 0.4 nTPM
  • hypothalamus: 0.4 nTPM
  • medulla oblongata: 0.4 nTPM

OntologyGO

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SCYGR10 as an antibody target. Whether an autoantibody or antibody against SCYGR10 could matter depends on whether native SCYGR10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SCYGR10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SCYGR10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SCYGR10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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