SCT
Secretin
Also known as: SECR_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P09683
- Gene
- SCT
- Ensembl
- ENSG00000070031
- Chromosome
- 11
- Canonical length
- 121 aa
- Protein class
- Predicted secreted proteins
- Secretome location
- Secreted to blood
OverviewNCBI Gene
This gene encodes a member of the glucagon family of peptides. The encoded preproprotein is secreted by endocrine S cells in the proximal small intestinal mucosa as a prohormone, then proteolytically processed to generate the mature peptide hormone. The release of this active peptide hormone is stimulated by either fatty acids or acidic pH in the duodenum. This hormone stimulates the secretion of bile and bicarbonate in the duodenum, pancreatic and biliary ducts. [provided by RefSeq, Feb 2016]
Canonical amino-acid sequenceUniProt
121 residues, UniProt reviewed canonical sequence.
>P09683|SCT
1 MAPRPLLLLL LLLGGSAARP APPRARRHSD GTFTSELSRL REGARLQRLL QGLVGKRSEQ
61 DAENSMAWTR LSAGLLCPSG SNMPILQAWM PLDGTWSPWL PPGPMVSEPA GAAAEGTLRP
121 RLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SCT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.63
- Highest tissue expression
- 42 nTPM
Expression across tissuesHPA
Tissue
- duodenum: 42 nTPM
- skeletal muscle: 9.7 nTPM
- small intestine: 8.1 nTPM
- spleen: 3.9 nTPM
- testis: 3.5 nTPM
- lung: 2.4 nTPM
Single-cell type
- neuroendocrine cells: 764 nCPM
- pdcs: 280 nCPM
- enterocytes: 47 nCPM
- thymic myoid cells: 25 nCPM
- undifferentiated spermatogonia: 20 nCPM
- gonadotrophs: 13 nCPM
Immune cell
- plasmacytoid DC: 127 nTPM
- NK-cell: 0.9 nTPM
- total PBMC: 0.4 nTPM
- basophil: 0.3 nTPM
- myeloid DC: 0.2 nTPM
- neutrophil: 0.2 nTPM
Brain region
- white matter: 17 nTPM
- cerebral cortex: 14 nTPM
- cerebellum: 13 nTPM
- pons: 13 nTPM
- basal ganglia: 12 nTPM
- thalamus: 12 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.97
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.2
- DepMap mean gene effect
- -0.03
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- adenylate cyclase-activating G protein-coupled receptor signaling pathway
- brain development
- diet induced thermogenesis
- embryonic digestive tract development
- hippocampus development
- intracellular water homeostasis
- pancreatic juice secretion
- positive regulation of cAMP/PKA signal transduction
- positive regulation of lipid catabolic process
- positive regulation of pancreatic juice secretion
- regulation of appetite
- regulation of synaptic plasticity
- response to nutrient levels
- negative regulation of gastrin-induced gastric acid secretion
- positive regulation of somatostatin secretion
Molecular functions
- G protein-coupled receptor binding
- hormone activity
- signaling receptor binding
- digestive hormone activity
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Glucagon/GIP/secretin/VIP
- Peptide hormone
- Secretin precursor
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SCT as an antibody target. Whether an autoantibody or antibody against SCT could matter depends on whether native SCT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SCT is annotated as secreted, so native SCT circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label SCT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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