SCRT1
Transcriptional repressor scratch 1
Also known as: DKFZp547F072, SCRT1_HUMAN, ZNF898
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9BWW7
- Gene
- SCRT1
- Ensembl
- ENSG00000261678
- Chromosome
- 8
- Canonical length
- 348 aa
- Protein class
- Plasma proteins, Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nuclear bodies
OverviewNCBI Gene
This gene encodes a C2H2-type zinc finger transcriptional repressor that binds to E-box motifs. The encoded protein may promote neural differention and may be involved in cancers with neuroendocrine features. [provided by RefSeq, Jul 2013]
Canonical amino-acid sequenceUniProt
348 residues, UniProt reviewed canonical sequence.
>Q9BWW7|SCRT1
1 MPRSFLVKKV KLDAFSSADL ESAYGRARSD LGAPLHDKGY LSDYVGPSSV YDGDAEAALL
61 KGPSPEPMYA AAVRGELGPA AAGSAPPPTP RPELATAAGG YINGDAAVSE GYAADAFFIT
121 DGRSRRKASN AGAAAAPSTA SAAAPDGDAG GGGGAGGRSL GSGPGGRGGT RAGAGTEARA
181 GPGAAGAGGR HACGECGKTY ATSSNLSRHK QTHRSLDSQL ARRCPTCGKV YVSMPAMAMH
241 LLTHDLRHKC GVCGKAFSRP WLLQGHMRSH TGEKPFGCAH CGKAFADRSN LRAHMQTHSA
301 FKHFQCKRCK KSFALKSYLN KHYESACFKG GAGGPAAPAP PQLSPVQALocalizationUniProt · AlphaFold · HPA
Whether an antibody against SCRT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.59
- Highest tissue expression
- 77 nTPM
Expression across tissuesHPA
Tissue
- cerebellum: 77 nTPM
- cerebral cortex: 53 nTPM
- basal ganglia: 21 nTPM
- midbrain: 20 nTPM
- hippocampal formation: 17 nTPM
- hypothalamus: 14 nTPM
Single-cell type
- brain excitatory neurons: 20 nCPM
- brain inhibitory neurons: 20 nCPM
- other brain neurons: 15 nCPM
- bergmann glia: 1.9 nCPM
- oligodendrocytes: 1.9 nCPM
- ependymal cells: 1.1 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebral cortex: 166 nTPM
- thalamus: 85 nTPM
- white matter: 78 nTPM
- medulla oblongata: 77 nTPM
- pons: 69 nTPM
- hypothalamus: 68 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about SCRT1.
Disease | ImmuneIEDB
Conditions an epitope on SCRT1 was assayed in.
- narcolepsy B cell
- multiple sclerosis B cell
- peripheral nervous system disease B cell
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.88
- gnomAD pLI
- 0.22
- gnomAD missense Z
- 2.43
- DepMap mean gene effect
- -0.17
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- negative regulation of transcription by RNA polymerase II
- regulation of DNA-templated transcription
- regulation of neuron migration
Molecular functions
- DNA-binding transcription factor activity
- DNA-binding transcription factor activity, RNA polymerase II-specific
- DNA-binding transcription repressor activity, RNA polymerase II-specific
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
- sequence-specific DNA binding
- sequence-specific double-stranded DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SCRT1 as an antibody target. Whether an autoantibody or antibody against SCRT1 could matter depends on whether native SCRT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SCRT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SCRT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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