Seroatlas · Human Serome Atlas

SCRN3

Secernin-3

Also known as: FLJ23142, SCRN3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q0VDG4
Gene: SCRN3
Ensembl: ENSG00000144306
Chromosome: 2
Canonical length: 424 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Vesicles,Cytosol

OverviewNCBI Gene

Predicted to enable cysteine-type exopeptidase activity and dipeptidase activity. Predicted to be involved in detection of temperature stimulus involved in sensory perception of pain. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

424 residues, UniProt reviewed canonical sequence.

>Q0VDG4|SCRN3
     1  MEPFSCDTFV ALPPATVDNR IIFGKNSDRL YDEVQEVVYF PAVVHDNLGE RLKCTYIEID
    61  QVPETYAVVL SRPAWLWGAE MGANEHGVCI GNEAVWGREE VCDEEALLGM DLVRLGLERA
   121  DTAEKALNVI VDLLEKYGQG GNCTEGRMVF SYHNSFLIAD RNEAWILETA GKYWAAEKVQ
   181  EGVRNISNQL SITTKIAREH PDMRNYAKRK GWWDGKKEFD FAAAYSYLDT AKMMTSSGRY
   241  CEGYKLLNKH KGNITFETMM EILRDKPSGI NMEGEFLTTA SMVSILPQDS SLPCIHFFTG
   301  TPDPERSVFK PFIFVPHISQ LLDTSSPTFE LEDLVKKKSH FKPDRRHPLY QKHQQALEVV
   361  NNNEEKAKIM LDNMRKLEKE LFREMESILQ NKHLDVEKIV NLFPQCTKDE IQIYQSNLSV
   421  KVSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SCRN3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.22
Highest tissue expression: 38 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 38 nTPM
tongue: 34 nTPM
parathyroid gland: 26 nTPM
heart muscle: 24 nTPM
cerebral cortex: 24 nTPM
spinal cord: 23 nTPM

Single-cell type

esophageal apical cells: 113 nCPM
enterocytes: 91 nCPM
epididymal principal cells: 75 nCPM
tuft cells: 69 nCPM
cardiomyocytes: 65 nCPM
megakaryocytes: 62 nCPM

Immune cell

neutrophil: 20 nTPM
naive B-cell: 11 nTPM
memory B-cell: 8.6 nTPM
plasmacytoid DC: 8.1 nTPM
naive CD4 T-cell: 7.9 nTPM
basophil: 7.3 nTPM

Brain region

white matter: 44 nTPM
medulla oblongata: 38 nTPM
cerebellum: 38 nTPM
basal ganglia: 37 nTPM
thalamus: 37 nTPM
hypothalamus: 36 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.14
gnomAD pLI: 0
gnomAD missense Z: -0.02
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Pyruvate

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SCRN3 as an antibody target. Whether an autoantibody or antibody against SCRN3 could matter depends on whether native SCRN3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SCRN3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SCRN3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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