Seroatlas · Human Serome Atlas

SCRN2

Secernin-2

Also known as: SCRN2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96FV2
Gene: SCRN2
Ensembl: ENSG00000141295
Chromosome: 17
Canonical length: 425 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

Predicted to enable cysteine-type exopeptidase activity and dipeptidase activity. Predicted to be involved in proteolysis. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

425 residues, UniProt reviewed canonical sequence.

>Q96FV2|SCRN2
     1  MASSSPDSPC SCDCFVSVPP ASAIPAVIFA KNSDRPRDEV QEVVFVPAGT HTPGSRLQCT
    61  YIEVEQVSKT HAVILSRPSW LWGAEMGANE HGVCIGNEAV WTKEPVGEGE ALLGMDLLRL
   121  ALERSSSAQE ALHVITGLLE HYGQGGNCLE DAAPFSYHST FLLADRTEAW VLETAGRLWA
   181  AQRIQEGARN ISNQLSIGTD ISAQHPELRT HAQAKGWWDG QGAFDFAQIF SLTQQPVRME
   241  AAKARFQAGR ELLRQRQGGI TAEVMMGILR DKESGICMDS GGFRTTASMV SVLPQDPTQP
   301  CVHFLTATPD PSRSVFKPFI FGMGVAQAPQ VLSPTFGAQD PVRTLPRFQT QVDRRHTLYR
   361  GHQAALGLME RDQDRGQQLQ QKQQDLEQEG LEATQGLLAG EWAPPLWELG SLFQAFVKRE
   421  SQAYA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SCRN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.22
Highest tissue expression: 76 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 76 nTPM
kidney: 69 nTPM
breast: 49 nTPM
duodenum: 41 nTPM
thyroid gland: 39 nTPM
liver: 38 nTPM

Single-cell type

enterocytes: 131 nCPM
epididymal efferent duct absorptive cells: 80 nCPM
paneth cells: 54 nCPM
fallopian tube ciliated cells: 54 nCPM
cytotrophoblasts: 51 nCPM
proximal tubule cells: 47 nCPM

Immune cell

eosinophil: 44 nTPM
naive CD4 T-cell: 32 nTPM
plasmacytoid DC: 30 nTPM
NK-cell: 29 nTPM
myeloid DC: 26 nTPM
naive B-cell: 25 nTPM

Brain region

choroid plexus: 19 nTPM
hypothalamus: 17 nTPM
spinal cord: 15 nTPM
white matter: 15 nTPM
medulla oblongata: 15 nTPM
midbrain: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.39
gnomAD pLI: 0
gnomAD missense Z: 0.22
DepMap mean gene effect: -0.24
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

proteolysis

Molecular functions

Cellular components

extracellular exosome

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Phosphoprotein

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SCRN2 as an antibody target. Whether an autoantibody or antibody against SCRN2 could matter depends on whether native SCRN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SCRN2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SCRN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...