Seroatlas · Human Serome Atlas

SCRN1

Secernin-1

Also known as: KIAA0193, SCRN1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q12765
Gene: SCRN1
Ensembl: ENSG00000136193
Chromosome: 7
Canonical length: 414 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

This gene likely encodes a member of the secernin family of proteins. A similar protein in rat functions in regulation of exocytosis in mast cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]

Canonical amino-acid sequenceUniProt

414 residues, UniProt reviewed canonical sequence.

>Q12765|SCRN1
     1  MAAAPPSYCF VAFPPRAKDG LVVFGKNSAR PRDEVQEVVY FSAADHEPES KVECTYISID
    61  QVPRTYAIMI SRPAWLWGAE MGANEHGVCI ANEAINTREP AAEIEALLGM DLVRLGLERG
   121  ETAKEALDVI VSLLEEHGQG GNYFEDANSC HSFQSAYLIV DRDEAWVLET IGKYWAAEKV
   181  TEGVRCICSQ LSLTTKMDAE HPELRSYAQS QGWWTGEGEF NFSEVFSPVE DHLDCGAGKD
   241  SLEKQEESIT VQTMMNTLRD KASGVCIDSE FFLTTASGVS VLPQNRSSPC IHYFTGTPDP
   301  SRSIFKPFIF VDDVKLVPKT QSPCFGDDDP AKKEPRFQEK PDRRHELYKA HEWARAIIES
   361  DQEQGRKLRS TMLELEKQGL EAMEEILTSS EPLDPAEVGD LFYDCVDTEI KFFK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SCRN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.22
Highest tissue expression: 158 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 158 nTPM
spinal cord: 132 nTPM
midbrain: 127 nTPM
cerebral cortex: 100 nTPM
retina: 95 nTPM
amygdala: 89 nTPM

Single-cell type

late spermatids: 126 nCPM
bergmann glia: 121 nCPM
cone photoreceptor cells: 116 nCPM
corticotrophs: 107 nCPM
müller glia: 98 nCPM
gonadotrophs: 90 nCPM

Immune cell

non-classical monocyte: 26 nTPM
intermediate monocyte: 14 nTPM
memory B-cell: 14 nTPM
myeloid DC: 11 nTPM
plasmacytoid DC: 11 nTPM
MAIT T-cell: 11 nTPM

Brain region

midbrain: 304 nTPM
hypothalamus: 238 nTPM
cerebellum: 229 nTPM
thalamus: 225 nTPM
white matter: 224 nTPM
spinal cord: 210 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SCRN1.

Disease | ImmuneIEDB

Conditions an epitope on SCRN1 was assayed in.

skin melanoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.69
gnomAD pLI: 0
gnomAD missense Z: 0.91
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SCRN1 as an antibody target. Whether an autoantibody or antibody against SCRN1 could matter depends on whether native SCRN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SCRN1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SCRN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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