SCRG1
Scrapie-responsive protein 1
Also known as: SCRG-1, SCRG1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O75711
- Gene
- SCRG1
- Ensembl
- ENSG00000164106
- Chromosome
- 4
- Canonical length
- 98 aa
- Protein class
- Predicted secreted proteins
- Secretome location
- Secreted in brain
OverviewNCBI Gene
Scrapie-responsive gene 1 is associated with neurodegenerative changes observed in transmissible spongiform encephalopathies. It may play a role in host response to prion-associated infections. The scrapie responsive protein 1 may be partly included in the membrane or secreted by the cells due to its hydrophobic N-terminus. In addition, the encoded protein can interact with bone marrow stromal cell antigen 1 (BST1) to enhance the differentiation potentials of human mesenchymal stem cells during tissue and bone regeneration. [provided by RefSeq, Jul 2016]
Canonical amino-acid sequenceUniProt
98 residues, UniProt reviewed canonical sequence.
>O75711|SCRG1
1 MKLMVLVFTI GLTLLLGVQA MPANRLSCYR KILKDHNCHN LPEGVADLTQ IDVNVQDHFW
61 DGKGCEMICY CNFSELLCCP KDVFFGPKIS FVIPCNNQLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SCRG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.42
- Highest tissue expression
- 38 nTPM
Expression across tissuesHPA
Tissue
- spinal cord: 38 nTPM
- midbrain: 33 nTPM
- amygdala: 29 nTPM
- basal ganglia: 29 nTPM
- cerebral cortex: 25 nTPM
- hippocampal formation: 22 nTPM
Single-cell type
- oligodendrocyte progenitor cells: 174 nCPM
- müller glia: 132 nCPM
- sertoli cells: 109 nCPM
- oligodendrocytes: 109 nCPM
- astrocytes: 84 nCPM
- smooth muscle cells: 53 nCPM
Immune cell
- basophil: 1.4 nTPM
- neutrophil: 1.1 nTPM
- classical monocyte: 0.5 nTPM
- NK-cell: 0.4 nTPM
- non-classical monocyte: 0.4 nTPM
- eosinophil: 0.3 nTPM
Brain region
- white matter: 26 nTPM
- medulla oblongata: 23 nTPM
- spinal cord: 20 nTPM
- cerebellum: 18 nTPM
- hypothalamus: 18 nTPM
- pons: 18 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.72
- gnomAD pLI
- 0.04
- gnomAD missense Z
- -0.02
- DepMap mean gene effect
- 0.15
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Scrapie-responsive protein 1
- Scrapie-responsive protein 1
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SCRG1 as an antibody target. Whether an autoantibody or antibody against SCRG1 could matter depends on whether native SCRG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SCRG1 is annotated as secreted, so native SCRG1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label SCRG1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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