Seroatlas · Human Serome Atlas

SCP2D1

SCP2 sterol-binding domain-containing protein 1

Also known as: C20orf79, dJ1068E13.2, HSD22, SCP2D_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UJQ7
Gene
SCP2D1
Ensembl
ENSG00000132631
Chromosome
20
Canonical length
156 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

156 residues, UniProt reviewed canonical sequence.

>Q9UJQ7|SCP2D1
     1  MWKRSDHQPK IKAEDGPLVG QFEVLGSVPE PAMPHPLELS EFESFPVFQD IRLHIREVGA
    61  QLVKKVNAVF QLDITKNGKT ILRWTIDLKN GSGDMYPGPA RLPADTVFTI PESVFMELVL
   121  GKMNPQKAFL AGKFKVSGKV LLSWKLERVF KDWAKF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SCP2D1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
62 nTPM

Expression across tissuesHPA

Tissue

  • testis: 62 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM
  • basal ganglia: 0 nTPM

Single-cell type

  • late spermatids: 1,251 nCPM
  • early spermatids: 1,214 nCPM
  • late primary spermatocytes: 43 nCPM
  • sertoli cells: 5.4 nCPM
  • leydig cells: 2.3 nCPM
  • differentiating spermatogonia: 1.1 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • amygdala: 0.1 nTPM
  • basal ganglia: 0.1 nTPM
  • cerebellum: 0.1 nTPM
  • cerebral cortex: 0.1 nTPM
  • hypothalamus: 0.1 nTPM
  • medulla oblongata: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.84
gnomAD pLI
0.01
gnomAD missense Z
0.35
DepMap mean gene effect
0.09
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SCP2D1 as an antibody target. Whether an autoantibody or antibody against SCP2D1 could matter depends on whether native SCP2D1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SCP2D1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SCP2D1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SCP2D1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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