Seroatlas · Human Serome Atlas

SCML1

Sex comb on midleg-like protein 1

Also known as: SCML1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UN30
Gene: SCML1
Ensembl: ENSG00000047634
Chromosome: X
Canonical length: 329 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to be located in female germ cell nucleus and male germ cell nucleus. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

329 residues, UniProt reviewed canonical sequence.

>Q9UN30|SCML1
     1  MMSNSSSEID VIKTRIPTYD EDDNTILYAY ETKPEFVNKE PNIVSDASCN TEEQLKTVDD
    61  VLIHCQVIYD ALQNLDKKID VIRRKVSKIQ RFHARSLWTN HKRYGYKKHS YRLVKKLKLQ
   121  KMKKNEVYET FSYPESYSPT LPVSRRENNS PSNLPRPSFC MEEYQRAELE EDPILSRTPS
   181  PVHPSDFSEH NCQPYYASDG ATYGSSSGLC LGNPRADSIH NTYSTDHASA APPSVTRSPV
   241  ENDGYIEEGS ITKHPSTWSV EAVVLFLKQT DPLALCPLVD LFRSHEIDGK ALLLLTSDVL
   301  LKHLGVKLGT AVKLCYYIDR LKQGKCFEN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SCML1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

retina: 29 nTPM
liver: 27 nTPM
testis: 25 nTPM
ovary: 20 nTPM
tongue: 14 nTPM
skeletal muscle: 12 nTPM

Single-cell type

early primary spermatocytes: 933 nCPM
sertoli cells: 689 nCPM
rod photoreceptor cells: 249 nCPM
myonuclei: 183 nCPM
leydig cells: 172 nCPM
ovarian stromal cells: 149 nCPM

Immune cell

naive CD4 T-cell: 19 nTPM
NK-cell: 9.6 nTPM
naive CD8 T-cell: 9 nTPM
non-classical monocyte: 4.3 nTPM
naive B-cell: 3.7 nTPM
intermediate monocyte: 3.5 nTPM

Brain region

cerebral cortex: 8 nTPM
choroid plexus: 7.2 nTPM
medulla oblongata: 7 nTPM
white matter: 6 nTPM
hypothalamus: 5.9 nTPM
pons: 5.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.29
gnomAD pLI: 0.96
gnomAD missense Z: 2.27
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

negative regulation of DNA-templated transcription

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SCML1 as an antibody target. Whether an autoantibody or antibody against SCML1 could matter depends on whether native SCML1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SCML1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SCML1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...