SCGB3A2
Secretoglobin family 3A member 2
Also known as: LU103, PNSP1, SG3A2_HUMAN, UGRP1
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96PL1
- Gene
- SCGB3A2
- Ensembl
- ENSG00000164265
- Chromosome
- 5
- Canonical length
- 93 aa
- Protein class
- Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins
- Secretome location
- Secreted in other tissues
- Quaternary structure
- Homodimer
OverviewNCBI Gene
The protein encoded by this gene is a secreted lung surfactant protein and a downstream target of thyroid transcription factor. A single nucleotide polymorphism in the promoter of this gene results in susceptibility to asthma.[provided by RefSeq, Mar 2010]
Canonical amino-acid sequenceUniProt
93 residues, UniProt reviewed canonical sequence.
>Q96PL1|SCGB3A2
1 MKLVTIFLLV TISLCSYSAT AFLINKVPLP VDKLAPLPLD NILPFMDPLK LLLKTLGISV
61 EHLVEGLRKC VNELGPEASE AVKKLLEALS HLVLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SCGB3A2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.49
- Highest tissue expression
- 1,194 nTPM
Expression across tissuesHPA
Tissue
- lung: 1,194 nTPM
- blood vessel: 9.8 nTPM
- retina: 9.5 nTPM
- thyroid gland: 6.7 nTPM
- salivary gland: 5.8 nTPM
- epididymis: 4.7 nTPM
Single-cell type
- transitional alveolar cells: 15,919 nCPM
- alveolar cells type 2: 759 nCPM
- alveolar cells type 1: 480 nCPM
- oocytes: 405 nCPM
- respiratory deuterosomal cells: 155 nCPM
- respiratory ciliated cells: 119 nCPM
Immune cell
- basophil: 72 nTPM
- NK-cell: 1.4 nTPM
- classical monocyte: 1 nTPM
- non-classical monocyte: 0.9 nTPM
- intermediate monocyte: 0.7 nTPM
- myeloid DC: 0.6 nTPM
Brain region
- hypothalamus: 44 nTPM
- cerebral cortex: 43 nTPM
- cerebellum: 40 nTPM
- medulla oblongata: 37 nTPM
- basal ganglia: 36 nTPM
- hippocampal formation: 35 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.87
- gnomAD pLI
- 0.01
- gnomAD missense Z
- 0.11
- DepMap mean gene effect
- 0.02
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of SCGB3A2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SCGB3A2 as an antibody target. Whether an autoantibody or antibody against SCGB3A2 could matter depends on whether native SCGB3A2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SCGB3A2 is annotated as secreted, so native SCGB3A2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label SCGB3A2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...