Seroatlas · Human Serome Atlas

SCGB3A1

Secretoglobin family 3A member 1

Also known as: HIN-1, HIN1, LU105, PnSP-2, SG3A1_HUMAN, UGRP2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96QR1
Gene: SCGB3A1
Ensembl: ENSG00000161055
Chromosome: 5
Canonical length: 104 aa
Protein class: Plasma proteins, Predicted secreted proteins
Secretome location: Secreted to blood
Quaternary structure: Homodimer

OverviewNCBI Gene

Predicted to enable cytokine activity. Predicted to be involved in positive regulation of myoblast fusion. Located in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

104 residues, UniProt reviewed canonical sequence.

>Q96QR1|SCGB3A1
     1  MKLAALLGLC VALSCSSAAA FLVGSAKPVA QPVAALESAA EAGAGTLANP LGTLNPLKLL
    61  LSSLGIPVNH LIEGSQKCVA ELGPQAVGAV KALKALLGAL TVFG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SCGB3A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 829 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 829 nTPM
lung: 613 nTPM
cervix: 253 nTPM
breast: 115 nTPM
esophagus: 81 nTPM
stomach: 48 nTPM

Single-cell type

respiratory secretory cells: 29,303 nCPM
submucosal glandular cells: 27,329 nCPM
prostatic club cells: 13,119 nCPM
respiratory deuterosomal cells: 11,754 nCPM
conjunctival goblet cells: 7,816 nCPM
salivary acinar cells: 3,810 nCPM

Immune cell

non-classical monocyte: 52 nTPM
eosinophil: 20 nTPM
intermediate monocyte: 17 nTPM
MAIT T-cell: 13 nTPM
myeloid DC: 10 nTPM
naive CD4 T-cell: 5.9 nTPM

Brain region

choroid plexus: 24 nTPM
hypothalamus: 12 nTPM
midbrain: 2.4 nTPM
white matter: 2.1 nTPM
medulla oblongata: 1.9 nTPM
basal ganglia: 1.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.84
gnomAD pLI: 0.03
gnomAD missense Z: 0.32
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

cytokine activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SCGB3A1 as an antibody target. Whether an autoantibody or antibody against SCGB3A1 could matter depends on whether native SCGB3A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SCGB3A1 is annotated as secreted, so native SCGB3A1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label SCGB3A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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