Seroatlas · Human Serome Atlas

SCGB2B2

Secretoglobin family 2B member 2

Also known as: SC2B2_HUMAN, SCGB4A2, SCGBL

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q4G0G5
Gene
SCGB2B2
Ensembl
ENSG00000205209
Chromosome
19
Canonical length
96 aa
Protein class
Predicted secreted proteins
Secretome location
Secreted in other tissues

OverviewNCBI Gene

Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

96 residues, UniProt reviewed canonical sequence.

>Q4G0G5|SCGB2B2
     1  MRVTSATCAL LLALICSVQL GDACLDIDKL LANVVFDVSQ DLLKEELARY NPSPLTEESF
    61  LNVQQCFANV SVTERFAHSV VIKKILQSND CIEAAF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SCGB2B2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
8.1 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 8.1 nTPM
  • skin: 2.7 nTPM
  • epididymis: 2.5 nTPM
  • breast: 2.3 nTPM
  • retina: 1.8 nTPM
  • testis: 1.7 nTPM

Single-cell type

  • early spermatids: 179 nCPM
  • myonuclei: 169 nCPM
  • sertoli cells: 156 nCPM
  • adrenal cortex cells: 110 nCPM
  • oligodendrocytes: 104 nCPM
  • astrocytes: 100 nCPM

Immune cell

  • basophil: 0.6 nTPM
  • eosinophil: 0.3 nTPM
  • naive CD4 T-cell: 0.3 nTPM
  • naive B-cell: 0.2 nTPM
  • total PBMC: 0.2 nTPM
  • classical monocyte: 0.1 nTPM

Brain region

  • white matter: 8 nTPM
  • thalamus: 7.2 nTPM
  • basal ganglia: 7 nTPM
  • pons: 7 nTPM
  • cerebral cortex: 6.9 nTPM
  • hypothalamus: 6.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.89
gnomAD pLI
0
gnomAD missense Z
-0.23
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SCGB2B2 as an antibody target. Whether an autoantibody or antibody against SCGB2B2 could matter depends on whether native SCGB2B2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SCGB2B2 is annotated as secreted, so native SCGB2B2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label SCGB2B2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SCGB2B2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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