Seroatlas · Human Serome Atlas

SCGB2A1

Mammaglobin-B

Also known as: LPHC, MGB2, MGC71973, SG2A1_HUMAN, UGB3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O75556
Gene
SCGB2A1
Ensembl
ENSG00000124939
Chromosome
11
Canonical length
95 aa
Protein class
Cancer-related genes, Predicted secreted proteins
Subcellular location
Vesicles
Secretome location
Secreted in other tissues

OverviewNCBI Gene

Involved in androgen receptor signaling pathway. Located in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

95 residues, UniProt reviewed canonical sequence.

>O75556|SCGB2A1
     1  MKLLMVLMLA ALLLHCYADS GCKLLEDMVE KTINSDISIP EYKELLQEFI DSDAAAEAMG
    61  KFKQCFLNQS HRTLKNFGLM MHTVYDSIWC NMKSN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SCGB2A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
1,903 nTPM

Expression across tissuesHPA

Tissue

  • cervix: 1,903 nTPM
  • epididymis: 1,294 nTPM
  • fallopian tube: 224 nTPM
  • endometrium: 80 nTPM
  • breast: 54 nTPM
  • stomach: 43 nTPM

Single-cell type

  • endometrial glandular cells: 4,106 nCPM
  • endometrial ciliated cells: 2,394 nCPM
  • epididymal principal cells: 2,332 nCPM
  • endometrial luminal cells: 1,609 nCPM
  • fallopian tube ciliated cells: 1,207 nCPM
  • epididymal efferent duct ciliated cells: 1,199 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • medulla oblongata: 7.7 nTPM
  • midbrain: 2.9 nTPM
  • hypothalamus: 2.3 nTPM
  • spinal cord: 1.1 nTPM
  • pons: 0.5 nTPM
  • white matter: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.41
gnomAD pLI
0.23
gnomAD missense Z
0.17
DepMap mean gene effect
-0.15
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SCGB2A1 as an antibody target. Whether an autoantibody or antibody against SCGB2A1 could matter depends on whether native SCGB2A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SCGB2A1 is annotated as secreted, so native SCGB2A1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label SCGB2A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SCGB2A1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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