Seroatlas · Human Serome Atlas

SCGB1D4

Secretoglobin family 1D member 4

Also known as: IIS, SG1D4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6XE38
Gene
SCGB1D4
Ensembl
ENSG00000197745
Chromosome
11
Canonical length
83 aa
Protein class
Predicted secreted proteins
Secretome location
Secreted in other tissues

OverviewNCBI Gene

Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

83 residues, UniProt reviewed canonical sequence.

>Q6XE38|SCGB1D4
     1  MRLSVCLLMV SLALCCYQAH ALVCPAVASE ITVFLFLSDA AVNLQVAKLN PPPEALAAKL
    61  EVKHCTDQIS FKKRLSLKKS WWK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SCGB1D4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
79 nTPM

Expression across tissuesHPA

Tissue

  • fallopian tube: 79 nTPM
  • cervix: 49 nTPM
  • epididymis: 41 nTPM
  • endometrium: 9 nTPM
  • seminal vesicle: 2.7 nTPM
  • testis: 1 nTPM

Single-cell type

  • endometrial ciliated cells: 4,189 nCPM
  • fallopian tube ciliated cells: 1,180 nCPM
  • endometrial glandular cells: 847 nCPM
  • epididymal efferent duct absorptive cells: 809 nCPM
  • endometrial luminal cells: 484 nCPM
  • endometrial stromal cells: 200 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 0.1 nTPM
  • white matter: 0.1 nTPM
  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • choroid plexus: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.6
gnomAD pLI
0.06
gnomAD missense Z
0.67
DepMap mean gene effect
0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SCGB1D4 as an antibody target. Whether an autoantibody or antibody against SCGB1D4 could matter depends on whether native SCGB1D4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SCGB1D4 is annotated as secreted, so native SCGB1D4 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label SCGB1D4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SCGB1D4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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