Seroatlas · Human Serome Atlas

SCGB1D1

Secretoglobin family 1D member 1

Also known as: LIPA, LPHA, MGC71958, SG1D1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95968
Gene
SCGB1D1
Ensembl
ENSG00000168515
Chromosome
11
Canonical length
90 aa
Protein class
Predicted secreted proteins
Secretome location
Secreted in other tissues

OverviewNCBI Gene

The protein encoded by this gene is a member of the lipophilin subfamily, part of the uteroglobin superfamily, and is an ortholog of prostatein, the major secretory glycoprotein of the rat ventral prostate gland. This gene product represents one component of a heterodimeric molecule present in human tears whose elution profile is consistent with prostatein, a tetrameric molecule composed of three peptide components in heterodimers. Assuming that human lipophilins are the functional counterparts of prostatein, they may be transcriptionally regulated by steroid hormones, with the ability to bind androgens, other steroids and possibly bind and concentrate estramustine, a chemotherapeutic agent widely used for prostate cancer. Although the gene has been reported to be on chromosome 15, this sequence appears to be from a cluster of genes on chromosome 11 that includes mammaglobin 2. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

90 residues, UniProt reviewed canonical sequence.

>O95968|SCGB1D1
     1  MRLSVCLLLL TLALCCYRAN AVVCQALGSE ITGFLLAGKP VFKFQLAKFK APLEAVAAKM
    61  EVKKCVDTMA YEKRVLITKT LGKIAEKCDR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SCGB1D1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
1.1 nTPM

Expression across tissuesHPA

Tissue

  • cervix: 1.1 nTPM
  • fallopian tube: 0.8 nTPM
  • thymus: 0.6 nTPM
  • endometrium: 0.3 nTPM
  • breast: 0.1 nTPM
  • esophagus: 0.1 nTPM

Single-cell type

  • lacrimal acinar cells: 42 nCPM
  • neutrophils: 13 nCPM
  • plasma cells: 7.9 nCPM
  • retinal pigment epithelial cells: 4.3 nCPM
  • epididymal principal cells: 3.2 nCPM
  • epididymal clear cells: 2 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hypothalamus: 0.9 nTPM
  • hippocampal formation: 0.3 nTPM
  • amygdala: 0.1 nTPM
  • basal ganglia: 0.1 nTPM
  • medulla oblongata: 0.1 nTPM
  • midbrain: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.97
gnomAD pLI
0
gnomAD missense Z
-0.14
DepMap mean gene effect
-0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SCGB1D1 as an antibody target. Whether an autoantibody or antibody against SCGB1D1 could matter depends on whether native SCGB1D1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SCGB1D1 is annotated as secreted, so native SCGB1D1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label SCGB1D1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SCGB1D1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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