Seroatlas · Human Serome Atlas

SCGB1C2

Secretoglobin family 1C member 2

Also known as: SG1C2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0DMR2
Gene
SCGB1C2
Ensembl
ENSG00000268320
Chromosome
17
Canonical length
95 aa
Protein class
Predicted secreted proteins
Secretome location
Secreted in other tissues

OverviewNCBI Gene

Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

95 residues, UniProt reviewed canonical sequence.

>P0DMR2|SCGB1C2
     1  MKGSRALLLV ALTLFCICRM ATGEDNDEFF MDFLQTLLVG TPEELYEGTL GKYNVNEDAK
    61  AAMTELKSCR DGLQPMHKAE LVKLLVQVLG SQDGA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SCGB1C2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
1.4 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 1.4 nTPM
  • retina: 0.9 nTPM
  • kidney: 0.5 nTPM
  • heart muscle: 0.3 nTPM
  • appendix: 0.1 nTPM
  • bone marrow: 0.1 nTPM

Single-cell type

  • platelets: 56 nCPM
  • late spermatids: 1.7 nCPM
  • müller glia: 1.1 nCPM
  • neuroendocrine cells: 0.5 nCPM
  • late primary spermatocytes: 0.3 nCPM
  • cdc: 0.1 nCPM

Immune cell

  • neutrophil: 0.6 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • white matter: 0.4 nTPM
  • cerebellum: 0.3 nTPM
  • cerebral cortex: 0.3 nTPM
  • hypothalamus: 0.3 nTPM
  • midbrain: 0.3 nTPM
  • pons: 0.3 nTPM

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SCGB1C2 as an antibody target. Whether an autoantibody or antibody against SCGB1C2 could matter depends on whether native SCGB1C2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SCGB1C2 is annotated as secreted, so native SCGB1C2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label SCGB1C2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SCGB1C2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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