Seroatlas · Human Serome Atlas

SCGB1C1

Secretoglobin family 1C member 1

Also known as: RYD5, SG1C1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TD33
Gene
SCGB1C1
Ensembl
ENSG00000188076
Chromosome
11
Canonical length
95 aa
Protein class
Predicted secreted proteins
Secretome location
Secreted - unknown location

OverviewNCBI Gene

Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

95 residues, UniProt reviewed canonical sequence.

>Q8TD33|SCGB1C1
     1  MKGSRALLLV ALTLFCICRM ATGEDNDEFF MDFLQTLLVG TPEELYEGTL GKYNVNEDAK
    61  AAMTELKSCI DGLQPMHKAE LVKLLVQVLG SQDGA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SCGB1C1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
3.1 nTPM

Expression across tissuesHPA

Tissue

  • retina: 3.1 nTPM
  • pancreas: 1.4 nTPM
  • salivary gland: 1 nTPM
  • bone marrow: 0.6 nTPM
  • kidney: 0.4 nTPM
  • adrenal gland: 0.1 nTPM

Single-cell type

  • platelets: 28 nCPM
  • parietal cells: 1.8 nCPM
  • pancreatic acinar cells: 0.6 nCPM
  • late spermatids: 0.4 nCPM
  • differentiating spermatogonia: 0.2 nCPM
  • müller glia: 0.2 nCPM

Immune cell

  • basophil: 4.9 nTPM
  • total PBMC: 3.3 nTPM
  • neutrophil: 1.3 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • pons: 3.7 nTPM
  • cerebellum: 2.4 nTPM
  • cerebral cortex: 1.5 nTPM
  • basal ganglia: 1.1 nTPM
  • medulla oblongata: 1.1 nTPM
  • white matter: 1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.93
gnomAD pLI
0
gnomAD missense Z
-0.05

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SCGB1C1 as an antibody target. Whether an autoantibody or antibody against SCGB1C1 could matter depends on whether native SCGB1C1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SCGB1C1 is annotated as secreted, so native SCGB1C1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label SCGB1C1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SCGB1C1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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