Seroatlas · Human Serome Atlas

SCGB1A1

Uteroglobin

Also known as: CC10, CC16, CCSP, UGB, UTER_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P11684
Gene: SCGB1A1
Ensembl: ENSG00000149021
Chromosome: 11
Canonical length: 91 aa
Protein class: Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted in other tissues
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a member of the secretoglobin family of small secreted proteins. The encoded protein has been implicated in numerous functions including anti-inflammation, inhibition of phospholipase A2 and the sequestering of hydrophobic ligands. Defects in this gene are associated with a susceptibility to asthma. [provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

91 residues, UniProt reviewed canonical sequence.

>P11684|SCGB1A1
     1  MKLAVTLTLV TLALCCSSAS AEICPSFQRV IETLLMDTPS SYEAAMELFS PDQDMREAGA
    61  QLKKLVDTLP QKPRESIIKL MEKIAQSSLC N

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SCGB1A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 2,894 nTPM

Expression across tissuesHPA

Tissue

lung: 2,894 nTPM
fallopian tube: 313 nTPM
prostate: 91 nTPM
esophagus: 11 nTPM
spleen: 6.8 nTPM
tonsil: 5.6 nTPM

Single-cell type

respiratory secretory cells: 77,673 nCPM
respiratory deuterosomal cells: 30,130 nCPM
transitional alveolar cells: 12,586 nCPM
submucosal glandular cells: 4,556 nCPM
conjunctival goblet cells: 1,562 nCPM
prostatic hillock cells: 960 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 2 nTPM
thalamus: 1.5 nTPM
midbrain: 1.3 nTPM
cerebral cortex: 1.2 nTPM
amygdala: 0.7 nTPM
basal ganglia: 0.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.92
gnomAD pLI: 0
gnomAD missense Z: 0.15
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

phospholipase A2 inhibitor activity
polychlorinated biphenyl binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SCGB1A1 as an antibody target. Whether an autoantibody or antibody against SCGB1A1 could matter depends on whether native SCGB1A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SCGB1A1 is annotated as secreted, so native SCGB1A1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label SCGB1A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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