SCG5

Protein identityUniProt · HPA

UniProt accession

P05408

Gene

SCG5

Ensembl

ENSG00000166922

Chromosome

15

Canonical length

212 aa

Protein class

Predicted secreted proteins

Secretome location

Secreted to blood

OverviewNCBI Gene

This gene encodes a secreted chaperone protein that prevents the aggregation of other secreted proteins, including proteins that are associated with neurodegenerative and metabolic disease. The encoded protein may be best known for its role in the trafficking and activation of prohormone convertase PC2 (encoded by Gene ID: 5126). Phosphorylation of the encoded protein has been shown to have an inhibitory effect on its chaperone function. This gene also produces a ARHGAP11A-SCG5 readthrough transcript and ARHGAP11A-SCG5 protein. [provided by RefSeq, Feb 2019]

Canonical amino-acid sequenceUniProt

212 residues, UniProt reviewed canonical sequence.

>P05408|SCG5
     1  MVSRMVSTML SGLLFWLASG WTPAFAYSPR TPDRVSEADI QRLLHGVMEQ LGIARPRVEY
    61  PAHQAMNLVG PQSIEGGAHE GLQHLGPFGN IPNIVAELTG DNIPKDFSED QGYPDPPNPC
   121  PVGKTADDGC LENTPDTAEF SREFQLHQHL FDPEHDYPGL GKWNKKLLYE KMKGGERRKR
   181  RSVNPYLQGQ RLDNVVAKKS VPHFSDEDKD PE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SCG5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.54

Highest tissue expression

386 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SCG5.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 65 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Polyposis syndrome, hereditary mixed, 1

Disease | ImmuneIEDB

Conditions an epitope on SCG5 was assayed in.

• type 1 diabetes mellitus T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.22

gnomAD pLI

0

gnomAD missense Z

0.61

DepMap mean gene effect

-0.35

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• intracellular protein transport
• neuropeptide signaling pathway
• peptide hormone processing
• regulation of hormone secretion

Molecular functions

• enzyme inhibitor activity
• enzyme regulator activity
• GTP binding
• unfolded protein binding

Cellular components

• extracellular region
• nucleus
• secretory granule

Protein domainsUniProt · Pfam · InterPro

• Neuroendocrine 7B2 precursor
• Neuroendocrine protein 7B2 precursor (Secretogranin V)

KeywordsUniProt

• Chaperone
• Cleavage on pair of basic residues
• Disulfide bond
• Neuropeptide
• Phosphoprotein
• Secreted
• Signal
• Sulfation
• Transport

InteractionsUniProt · HPA

Protein binding partners of SCG5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• UBQLN1
• UBQLN4