SCG2

Protein identityUniProt · HPA

UniProt accession

P13521

Gene

SCG2

Ensembl

ENSG00000171951

Chromosome

2

Canonical length

617 aa

Protein class

Plasma proteins, Predicted secreted proteins

Subcellular location

Golgi apparatus,Vesicles

Secretome location

Secreted to blood

OverviewNCBI Gene

The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The full-length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and EM66, whose function is unknown. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

617 residues, UniProt reviewed canonical sequence.

>P13521|SCG2
     1  MAEAKTHWLG AALSLIPLIF LISGAEAASF QRNQLLQKEP DLRLENVQKF PSPEMIRALE
    61  YIENLRQQAH KEESSPDYNP YQGVSVPLQQ KENGDESHLP ERDSLSEEDW MRIILEALRQ
   121  AENEPQSAPK ENKPYALNSE KNFPMDMSDD YETQQWPERK LKHMQFPPMY EENSRDNPFK
   181  RTNEIVEEQY TPQSLATLES VFQELGKLTG PNNQKRERMD EEQKLYTDDE DDIYKANNIA
   241  YEDVVGGEDW NPVEEKIESQ TQEEVRDSKE NIEKNEQIND EMKRSGQLGI QEEDLRKESK
   301  DQLSDDVSKV IAYLKRLVNA AGSGRLQNGQ NGERATRLFE KPLDSQSIYQ LIEISRNLQI
   361  PPEDLIEMLK TGEKPNGSVE PERELDLPVD LDDISEADLD HPDLFQNRML SKSGYPKTPG
   421  RAGTEALPDG LSVEDILNLL GMESAANQKT SYFPNPYNQE KVLPRLPYGA GRSRSNQLPK
   481  AAWIPHVENR QMAYENLNDK DQELGEYLAR MLVKYPEIIN SNQVKRVPGQ GSSEDDLQEE
   541  EQIEQAIKEH LNQGSSQETD KLAPVSKRFP VGPPKNDDTP NRQYWDEDLL MKVLEYLNQE
   601  KAEKGREHIA KRAMENM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SCG2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.63

Highest tissue expression

392 nTPM

Expression across tissuesHPA

ReferencesPubMed · IEDB

Publications for SCG2 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.85

gnomAD pLI

0

gnomAD missense Z

-0.08

DepMap mean gene effect

-0.01

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• angiogenesis
• endothelial cell migration
• eosinophil chemotaxis
• induction of positive chemotaxis
• inflammatory response
• intracellular signal transduction
• MAPK cascade
• negative regulation of endothelial cell apoptotic process
• negative regulation of endothelial cell proliferation
• negative regulation of extrinsic apoptotic signaling pathway
• positive chemotaxis
• positive regulation of endothelial cell proliferation
• protein secretion

Molecular functions

• chemoattractant activity
• cytokine activity

Cellular components

• endoplasmic reticulum lumen
• extracellular space
• neuronal dense core vesicle
• secretory granule

Protein domainsUniProt · Pfam · InterPro

• Chromogranin A/B/C
• Chromogranin, conserved site
• Granin (chromogranin or secretogranin)
• Secretogranin-2

KeywordsUniProt

• Calcium
• Cleavage on pair of basic residues
• Glycoprotein
• Phosphoprotein
• Secreted
• Signal
• Sulfation