Seroatlas · Human Serome Atlas

SCEL

Sciellin

Also known as: FLJ21667, MGC22531, SCEL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95171
Gene
SCEL
Ensembl
ENSG00000136155
Chromosome
13
Canonical length
688 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a precursor to the cornified envelope of terminally differentiated keratinocytes. This protein localizes to the periphery of cells and may function in the assembly or regulation of proteins in the cornified envelope. Transcript variants encoding different isoforms exist. A transcript variant utilizing an alternative polyA signal has been described in the literature, but its full-length nature has not been determined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

688 residues, UniProt reviewed canonical sequence.

>O95171|SCEL
     1  MSNVTLRKMS PTGNEMKSTT QGTTRKQQDF HEVNKRRTFL QDNSWIKKRP EEEKDENYGR
    61  VVLNRHNSHD ALDRKVNERD VPKATISRYS SDDTLDRISD RNDAAKTYKA NTLDNQLTNR
   121  SMSMFRSLEV TKLQPGGSLN ANTSNTIAST SATTPVKKKR QSWFPPPPPG YNASSSTGTR
   181  RREPGVHPPI PPKPSSPVSS PNQLRQDNRQ IHPPKPGVYT ETNRSAERNI RSQDLDNIVK
   241  VATSLQRSDK GEELDNLIKM NKSLNRNQGL DSLFRANPKV EEREKRAKSL ESLIYMSTRT
   301  DKDGKGIQSL GSPIKVNQRT DKNEKGRQNL ESVAKVNARM NKTSRRSEDL DNATEVNPKG
   361  HENTTGKKDL DGLIKVDPET NKNITRGQSL DNLIKVTPEV KRSNQGSKDL NNFIKVYPGT
   421  EKSTEGGQSL DSLIKVTPER NRTNQGNQDL ENLIKVIPSA NKSSEQGLDE HINVSPKAVK
   481  NTDGKQDLDK LIKVNPEIFT NNQRNQDLAN LIKVNPAVIR NNQSQDLDNL IKVKPSALRN
   541  TNRDQNLENL IEVNSHVSEN KNGSSNTGAK QAGPQDTVVY TRTYVENSKS PKDGYQENIS
   601  GKYIQTVYST SDRSVIERDM CTYCRKPLGV ETKMILDELQ ICCHSTCFKC EICKQPLENL
   661  QAGDSIWIYR QTIHCEPCYS KIMAKWIP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SCEL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.66
Highest tissue expression
350 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 350 nTPM
  • skin: 286 nTPM
  • vagina: 109 nTPM
  • cervix: 99 nTPM
  • tonsil: 72 nTPM
  • lung: 56 nTPM

Single-cell type

  • esophageal apical cells: 7,220 nCPM
  • alveolar cells type 1: 845 nCPM
  • esophageal suprabasal cells: 746 nCPM
  • suprabasal keratinocytes: 460 nCPM
  • ocular epithelial cells: 297 nCPM
  • esophageal basal cells: 103 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • pons: 0.5 nTPM
  • white matter: 0.5 nTPM
  • midbrain: 0.4 nTPM
  • thalamus: 0.4 nTPM
  • basal ganglia: 0.3 nTPM
  • cerebellum: 0.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SCEL.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 140 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.01
gnomAD pLI
0
gnomAD missense Z
0.29
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SCEL as an antibody target. Whether an autoantibody or antibody against SCEL could matter depends on whether native SCEL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SCEL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SCEL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SCEL. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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