Seroatlas · Human Serome Atlas

SCART1

Scavenger receptor cysteine-rich domain-containing protein SCART1

Also known as: CD163c-alpha, SRCRM_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q4G0T1
Gene: SCART1
Ensembl: ENSG00000214279
Chromosome: 10
Canonical length: 1027 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to be involved in T cell mediated immunity. Located in brush border and cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1027 residues, UniProt reviewed canonical sequence.

>Q4G0T1|SCART1
     1  MRAALWTLGL GPLLLNLWAV PIGGPGALRL AYRHSTCDGV VLVRHHGAWG YVCNQEWTLA
    61  EASVVCRQLG CGPAVGAPKY VPLPGEMAQP WLHNVSCRGN ESSLWECSLG SWCQSPCPHA
   121  WVVVALCSNG TFRELRLVKG RSPCAGLPEI RNVNGVDRLC VLHVEEAMVF CRELGCGPVL
   181  QAPRRDVGVV RKYLACRGTE PTIRSCRLDN NFRSGCDLRL DAEVVCSGHT EARLVGGEHP
   241  CAGRLEVTWG TVCDAALDLA TAHVVCRELQ CGAVVSTPEG ARFGRGSGPV WTEAFRCAGN
   301  ESLLFHCPRG RGSQCGHGHD AGLRCSEFRM VNGSSSCEGR VEFQVQGSWA PLCATHWDIA
   361  DATVLCHQLN CGNAVAAPGG GHFGDGDAAI WPDAFHCEGT ESYLWNCPVS TLGAPACAPG
   421  NTASAVCSGL AHALRLREGQ SRCDGRVEVS LDGVWGRVLD DAWDLRGAGV VCRQLGCRGA
   481  QQAYDAPAPS RGSVQVALSR VRCLGTETRL TQCNVSATLQ EPAGTSRDAG VVCSGEVGTA
   541  SPMARRHGIP GALTLSLHRE PQGAAGRGAG ALHGGAWGTV CDDAWDLRDA HVVCRQLGCG
   601  RALSALGAAH FGAGAGRIWL DELGCQGHES ALWQCPSAGW GRHDWRHKED AGVFCSESVA
   661  LRLRGGTCCC AGWLDVFYNG TWGAMCSNAL KDLSLSIICK QLGCGVWGVG LAGEQALPLC
   721  GHRDRLGGQH RVPQAAQLHS VAMPFPPMAP ALLRPSRAGL SEDRPQAAGE PLNCSSWLGC
   781  PEEGALRVRG GEDRCSGRVE LWHAGSWGTV CDDGWDLADA EVVCRQLGCG RAVAALGAAA
   841  FGPGSGPVWL DEVGCRGSEA SLWGCPAERW GRGDRAHEED AGVRCWEPGP GPPLPAAPFR
   901  TFWVVSVVLG SLLGLLLLGL MAFLILPRVT QAMQRGLGRS EVSPGEAIYD VIGEMPPAGL
   961  YEEIMEAEAV LQDEEDGSVV KVDTEAAVSG EVSNLLEGQS IRAEGGHSRP VSQGYDEAAF
  1021  PLEEMTL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SCART1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 1 nTPM

Expression across tissuesHPA

Tissue

hippocampal formation: 1 nTPM
bone marrow: 0.8 nTPM
skin: 0.8 nTPM
epididymis: 0.7 nTPM
spleen: 0.7 nTPM
retina: 0.6 nTPM

Single-cell type

innate lymphoid cells: 106 nCPM
rod photoreceptor cells: 37 nCPM
esophageal apical cells: 37 nCPM
brain excitatory neurons: 35 nCPM
adrenal medulla cells: 32 nCPM
retinal bipolar cells: 32 nCPM

Immune cell

MAIT T-cell: 0.2 nTPM
basophil: 0.1 nTPM
gdT-cell: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM
memory CD8 T-cell: 0.1 nTPM
naive CD4 T-cell: 0.1 nTPM

Brain region

cerebral cortex: 18 nTPM
hippocampal formation: 18 nTPM
cerebellum: 12 nTPM
white matter: 10 nTPM
pons: 9 nTPM
basal ganglia: 8.9 nTPM

OntologyGO

Biological processes

T cell mediated immunity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SCART1 as an antibody target. Whether an autoantibody or antibody against SCART1 could matter depends on whether native SCART1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SCART1 is annotated at the cell surface, where native SCART1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SCART1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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