Seroatlas · Human Serome Atlas

SCARB2

Lysosome membrane protein 2

Also known as: CD36L2, HLGP85, LIMP-2, LIMPII, SCRB2_HUMAN, SR-BII

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q14108
Gene
SCARB2
Ensembl
ENSG00000138760
Chromosome
4
Canonical length
478 aa
Protein class
Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters
Subcellular location
Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. Further studies in human showed that this protein is a ubiquitously expressed protein and that it is involved in the pathogenesis of HFMD (hand, foot, and mouth disease) caused by enterovirus-71 and possibly by coxsackievirus A16. Mutations in this gene caused an autosomal recessive progressive myoclonic epilepsy-4 (EPM4), also known as action myoclonus-renal failure syndrome (AMRF). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]

Canonical amino-acid sequenceUniProt

478 residues, UniProt reviewed canonical sequence.

>Q14108|SCARB2
     1  MGRCCFYTAG TLSLLLLVTS VTLLVARVFQ KAVDQSIEKK IVLRNGTEAF DSWEKPPLPV
    61  YTQFYFFNVT NPEEILRGET PRVEEVGPYT YRELRNKANI QFGDNGTTIS AVSNKAYVFE
   121  RDQSVGDPKI DLIRTLNIPV LTVIEWSQVH FLREIIEAML KAYQQKLFVT HTVDELLWGY
   181  KDEILSLIHV FRPDISPYFG LFYEKNGTND GDYVFLTGED SYLNFTKIVE WNGKTSLDWW
   241  ITDKCNMING TDGDSFHPLI TKDEVLYVFP SDFCRSVYIT FSDYESVQGL PAFRYKVPAE
   301  ILANTSDNAG FCIPEGNCLG SGVLNVSICK NGAPIIMSFP HFYQADERFV SAIEGMHPNQ
   361  EDHETFVDIN PLTGIILKAA KRFQINIYVK KLDDFVETGD IRTMVFPVMY LNESVHIDKE
   421  TASRLKSMIN TTLIITNIPY IIMALGVFFG LVFTWLACKG QGSMDEGTAD ERAPLIRT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SCARB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
89 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 89 nTPM
  • salivary gland: 72 nTPM
  • liver: 67 nTPM
  • prostate: 65 nTPM
  • lung: 63 nTPM
  • placenta: 62 nTPM

Single-cell type

  • prostatic glandular cells: 501 nCPM
  • kupffer cells: 426 nCPM
  • oligodendrocytes: 300 nCPM
  • urothelial cells: 277 nCPM
  • thymic myoid cells: 271 nCPM
  • ocular epithelial cells: 214 nCPM

Immune cell

  • plasmacytoid DC: 29 nTPM
  • intermediate monocyte: 26 nTPM
  • non-classical monocyte: 25 nTPM
  • classical monocyte: 14 nTPM
  • basophil: 12 nTPM
  • myeloid DC: 8.1 nTPM

Brain region

  • white matter: 212 nTPM
  • medulla oblongata: 159 nTPM
  • basal ganglia: 154 nTPM
  • spinal cord: 151 nTPM
  • cerebellum: 148 nTPM
  • thalamus: 137 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SCARB2.

Disease | AllUniProt

Conditions SCARB2 is implicated in, by any mechanism.

  • Epilepsy, progressive myoclonic 4, with or without renal failure (EPM4) MIM:254900

Disease | GeneticClinVar

38 pathogenic / likely-pathogenic of 554 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.72
gnomAD pLI
0
gnomAD missense Z
1.32
DepMap mean gene effect
-0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SCARB2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SCARB2 as an antibody target. Whether an autoantibody or antibody against SCARB2 could matter depends on whether native SCARB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SCARB2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SCARB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SCARB2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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