Seroatlas · Human Serome Atlas

SCAMP4

Secretory carrier-associated membrane protein 4

Also known as: FLJ33847, SCAM4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q969E2
Gene: SCAMP4
Ensembl: ENSG00000227500
Chromosome: 19
Canonical length: 229 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Golgi apparatus,Vesicles,Lipid droplets,Plasma membrane

OverviewNCBI Gene

Secretory carrier membrane proteins (SCAMPs) are widely distributed integral membrane proteins implicated in membrane trafficking. Most SCAMPs (e.g., SCAMP1; MIM 606911) have N-terminal cytoplasmic NPF (arg-pro-phe) repeats, 4 central transmembrane regions, and a short C-terminal cytoplasmic tail. These SCAMPs likely have a role in endocytosis that is mediated by their NPF repeats. Other SCAMPs, such as SCAMP4, lack the NPF repeats and are therefore unlikely to function in endocytosis (summary by Fernandez-Chacon and Sudhof, 2000 [PubMed 11050114]).[supplied by OMIM, Feb 2011]

Canonical amino-acid sequenceUniProt

229 residues, UniProt reviewed canonical sequence.

>Q969E2|SCAMP4
     1  MSEKENNFPP LPKFIPVKPC FYQNFSDEIP VEHQVLVKRI YRLWMFYCAT LGVNLIACLA
    61  WWIGGGSGTN FGLAFVWLLL FTPCGYVCWF RPVYKAFRAD SSFNFMAFFF IFGAQFVLTV
   121  IQAIGFSGWG ACGWLSAIGF FQYSPGAAVV MLLPAIMFSV SAAMMAIAIM KVHRIYRGAG
   181  GSFQKAQTEW NTGTWRNPPS REAQYNNFSG NSLPEYPTVP SYPGSGQWP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SCAMP4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 71 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 71 nTPM
salivary gland: 41 nTPM
esophagus: 40 nTPM
midbrain: 38 nTPM
skin: 36 nTPM
fallopian tube: 36 nTPM

Single-cell type

respiratory ciliated cells: 96 nCPM
fallopian tube ciliated cells: 86 nCPM
endometrial ciliated cells: 61 nCPM
syncytiotrophoblasts: 54 nCPM
ependymal cells: 53 nCPM
alveolar cells type 1: 47 nCPM

Immune cell

plasmacytoid DC: 12 nTPM
NK-cell: 5.9 nTPM
memory B-cell: 5.2 nTPM
intermediate monocyte: 5.1 nTPM
myeloid DC: 4.9 nTPM
classical monocyte: 4.5 nTPM

Brain region

white matter: 101 nTPM
medulla oblongata: 99 nTPM
midbrain: 80 nTPM
cerebellum: 78 nTPM
pons: 76 nTPM
thalamus: 76 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.87
gnomAD pLI: 0
gnomAD missense Z: 0.2
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SCAMP4 as an antibody target. Whether an autoantibody or antibody against SCAMP4 could matter depends on whether native SCAMP4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SCAMP4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SCAMP4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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