Seroatlas · Human Serome Atlas

SCAI

Protein SCAI

Also known as: C9orf126, FLJ36664, NET40, SCAI_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N9R8
Gene: SCAI
Ensembl: ENSG00000173611
Chromosome: 9
Canonical length: 606 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear membrane

OverviewNCBI Gene

This gene encodes a regulator of cell migration. The encoded protein appears to function in the RhoA (ras homolog gene family, member A)-Dia1 (diaphanous homolog 1) signal transduction pathway. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]

Canonical amino-acid sequenceUniProt

606 residues, UniProt reviewed canonical sequence.

>Q8N9R8|SCAI
     1  MVRGARQPQQ PRSRLAPRLT GTVEKPPRKR RSRTEFALKE IMSSGGAEDD IPQGERKTVT
    61  DFCYLLDKSK QLFNGLRDLP QYGQKQWQSY FGRTFDVYTK LWKFQQQHRQ VLDNRYGLKR
   121  WQIGEIASKI GQLYYHYYLR TSETSYLNEA FSFYSAIRQR SYYSQVNKED RPELVVKKLR
   181  YYARFIVVCL LLNKMDVVKD LVKELSDEIE DYTHRFNTED QVEWNLVLQE VAAFIEADPV
   241  MVLNDDNTIV ITSNRLAETG APLLEQGMIV GQLSLADALI IGNCNNQVKF SELTVDMFRM
   301  LQALEREPMN LASQMNKPGM QESADKPTRR ENPHKYLLYK PTFSQLYTFL AASFKELPAN
   361  SVLLIYLSAT GVFPTGRSDS EGPYDFGGVL TNSNRDIING DAIHKRNQSH KEMHCLHPGD
   421  LYPFTRKPLF IIVDSSNSVA YKNFTNLFGQ PLVCLLSPTA YPKALQDQSQ RGSLFTLFLN
   481  NPLMAFLFVS GLSSMRRGLW EKCQEYLRKI NRDIAQLLTH SRSIDQAFLQ FFGDEFLRLL
   541  LTRFIFCSAT MRMHKIFRET RNYPESYPQL PRDETVENPH LQKHILELAS ILDVRNVFFE
   601  NTIDDY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SCAI can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 10 nTPM

Expression across tissuesHPA

Tissue

thymus: 10 nTPM
retina: 6.9 nTPM
cerebral cortex: 6.7 nTPM
basal ganglia: 3.3 nTPM
cerebellum: 3 nTPM
lung: 3 nTPM

Single-cell type

retinal pigment epithelial cells: 499 nCPM
choroid plexus epithelial cells: 432 nCPM
thymocytes: 272 nCPM
retinal amacrine cells: 262 nCPM
alveolar cells type 1: 257 nCPM
brain inhibitory neurons: 232 nCPM

Immune cell

plasmacytoid DC: 0.8 nTPM
T-reg: 0.7 nTPM
naive B-cell: 0.6 nTPM
naive CD4 T-cell: 0.6 nTPM
NK-cell: 0.6 nTPM
intermediate monocyte: 0.4 nTPM

Brain region

choroid plexus: 29 nTPM
cerebral cortex: 27 nTPM
basal ganglia: 25 nTPM
white matter: 19 nTPM
hippocampal formation: 18 nTPM
thalamus: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.24
gnomAD pLI: 1
gnomAD missense Z: 3.01
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

transcription corepressor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Protein SCAI, metazoan/viridiplantae
Protein SCAI
Protein SCAI

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SCAI in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

DIAPH1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SCAI as an antibody target. Whether an autoantibody or antibody against SCAI could matter depends on whether native SCAI is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SCAI is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SCAI as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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