SBK3
Uncharacterized serine/threonine-protein kinase SBK3
Also known as: SBK3_HUMAN, SgK110
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P0C264
- Gene
- SBK3
- Ensembl
- ENSG00000231274
- Chromosome
- 19
- Canonical length
- 359 aa
- Protein class
- Enzymes, Predicted intracellular proteins, Predicted membrane proteins
- Subcellular location
- Mitochondria
OverviewNCBI Gene
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in chromatin remodeling. [provided by Alliance of Genome Resources, Apr 2025]
Canonical amino-acid sequenceUniProt
359 residues, UniProt reviewed canonical sequence.
>P0C264|SBK3
1 MERRASETPE DGDPEEDTAT ALQRLVELTT SRVTPVRSLR DQYHLIRKLG SGSYGRVLLA
61 QPHQGGPAVA LKLLRRDLVL RSTFLREFCV GRCVSAHPGL LQTLAGPLQT PRYFAFAQEY
121 APCGDLSGML QERGLPELLV KRVVAQLAGA LDFLHSRGLV HADVKPDNVL VFDPVCSRVA
181 LGDLGLTRPE GSPTPAPPVP LPTAPPELCL LLPPDTLPLR PAVDSWGLGV LLFCAATACF
241 PWDVALAPNP EFEAFAGWVT TKPQPPQPPP PWDQFAPPAL ALLQGLLDLD PETRSPPLAV
301 LDFLGDDWGL QGNREGPGVL GSAVSYEDRE EGGSSLEEWT DEGDDSKSGG RTGTDGGAPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SBK3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.32
- Highest tissue expression
- 31 nTPM
Expression across tissuesHPA
Tissue
- heart muscle: 31 nTPM
- tongue: 14 nTPM
- skeletal muscle: 6.1 nTPM
- adipose tissue: 2.4 nTPM
- esophagus: 1.9 nTPM
- breast: 0.9 nTPM
Single-cell type
- cardiomyocytes: 2.2 nCPM
- thymic myoid cells: 1.4 nCPM
- mucous neck cells: 0.8 nCPM
- lymphatic endothelial cells: 0.6 nCPM
- vascular endothelial cells: 0.6 nCPM
- foveolar cells: 0.4 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebellum: 0.8 nTPM
- pons: 0.6 nTPM
- thalamus: 0.3 nTPM
- spinal cord: 0.2 nTPM
- white matter: 0.2 nTPM
- cerebral cortex: 0.1 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.69
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.59
OntologyGO
Molecular functions
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SBK3 as an antibody target. Whether an autoantibody or antibody against SBK3 could matter depends on whether native SBK3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SBK3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SBK3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...