SBK2
Serine/threonine-protein kinase SBK2
Also known as: SBK2_HUMAN, SGK069
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P0C263
- Gene
- SBK2
- Ensembl
- ENSG00000187550
- Chromosome
- 19
- Canonical length
- 348 aa
- Protein class
- Enzymes, Predicted membrane proteins
OverviewNCBI Gene
Predicted to enable MAP kinase kinase activity. Predicted to be involved in MAPK cascade. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
348 residues, UniProt reviewed canonical sequence.
>P0C263|SBK2
1 MPGKQSEEGP AEAGASEDSE EEGLGGLTLE ELQQGQEAAR ALEDMMTLSA QTLVRAEVDE
61 LYEEVRPLGQ GCYGRVLLVT HRQKGTPLAL KQLPKPRTSL RGFLYEFCVG LSLGAHSAIV
121 TAYGIGIESA HSYSFLTEPV LHGDLMAFIQ PKVGLPQPAV HRCAAQLASA LEYIHARGLV
181 YRDLKPENVL VCDPACRRFK LTDFGHTRPR GTLLRLAGPP IPYTAPELCA PPPLPEGLPI
241 QPALDAWALG VLLFCLLTGY FPWDRPLAEA DPFYEDFLIW QASGQPRDRP QPWFGLAAAA
301 DALLRGLLDP HPRRRSAVIA IREHLGRPWR QREGEAEAVG AVEEEAGQLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SBK2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.29
- Highest tissue expression
- 122 nTPM
Expression across tissuesHPA
Tissue
- heart muscle: 122 nTPM
- tongue: 27 nTPM
- skeletal muscle: 2.3 nTPM
- testis: 2.3 nTPM
- adipose tissue: 0.8 nTPM
- bone marrow: 0.6 nTPM
Single-cell type
- early spermatids: 8.6 nCPM
- late spermatids: 8.6 nCPM
- pancreatic islet cells: 3.1 nCPM
- epicardial cells: 2.3 nCPM
- mesothelial cells: 0.6 nCPM
- cardiomyocytes: 0.5 nCPM
Immune cell
- neutrophil: 0.8 nTPM
- basophil: 0.3 nTPM
- gdT-cell: 0.3 nTPM
- MAIT T-cell: 0.3 nTPM
- classical monocyte: 0.2 nTPM
- eosinophil: 0.2 nTPM
Brain region
- cerebellum: 3.5 nTPM
- choroid plexus: 3.4 nTPM
- white matter: 2.4 nTPM
- basal ganglia: 2.1 nTPM
- hippocampal formation: 2.1 nTPM
- medulla oblongata: 2.1 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.64
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.14
- DepMap mean gene effect
- -0.03
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SBK2 as an antibody target. Whether an autoantibody or antibody against SBK2 could matter depends on whether native SBK2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SBK2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SBK2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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