Seroatlas · Human Serome Atlas

SBK1

Serine/threonine-protein kinase SBK1

Also known as: Sbk, SBK1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q52WX2
Gene: SBK1
Ensembl: ENSG00000188322
Chromosome: 16
Canonical length: 424 aa
Protein class: Enzymes, Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in chromatin remodeling. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

424 residues, UniProt reviewed canonical sequence.

>Q52WX2|SBK1
     1  MSVGCPEPEP PRSLTCCGPG TAPGPGAGVP LLTEDMQALT LRTLAASDVT KHYELVRELG
    61  KGTYGKVDLV VYKGTGTKMA LKFVNKSKTK LKNFLREVSI TNSLSSSPFI IKVFDVVFET
   121  EDCYVFAQEY APAGDLFDII PPQVGLPEDT VKRCVQQLGL ALDFMHGRQL VHRDIKPENV
   181  LLFDRECRRV KLADFGMTRR VGCRVKRVSG TIPYTAPEVC QAGRADGLAV DTGVDVWAFG
   241  VLIFCVLTGN FPWEAASGAD AFFEEFVRWQ RGRLPGLPSQ WRRFTEPALR MFQRLLALEP
   301  ERRGPAKEVF RFLKHELTSE LRRRPSHRAR KPPGDRPPAA GPLRLEAPGP LKRTVLTESG
   361  SGSRPAPPAV GSVPLPVPVP VPVPVPVPVP EPGLAPQGPP GRTDGRADKS KGQVVLATAI
   421  EICV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SBK1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 43 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 43 nTPM
skeletal muscle: 41 nTPM
cerebral cortex: 16 nTPM
hippocampal formation: 13 nTPM
amygdala: 11 nTPM
thymus: 9.3 nTPM

Single-cell type

myonuclei: 218 nCPM
cone photoreceptor cells: 48 nCPM
retinal amacrine cells: 46 nCPM
corticotrophs: 23 nCPM
nk-cells: 19 nCPM
lactotrophs: 19 nCPM

Immune cell

gdT-cell: 1.5 nTPM
naive CD8 T-cell: 1 nTPM
memory CD8 T-cell: 0.8 nTPM
NK-cell: 0.7 nTPM
MAIT T-cell: 0.5 nTPM
T-reg: 0.5 nTPM

Brain region

cerebellum: 68 nTPM
cerebral cortex: 42 nTPM
thalamus: 39 nTPM
hippocampal formation: 36 nTPM
amygdala: 28 nTPM
midbrain: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.7
gnomAD pLI: 0.37
gnomAD missense Z: 2.94
DepMap mean gene effect: -0.23
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

Protein kinase domain
Serine/threonine-protein kinase, active site
Protein kinase-like domain superfamily
Protein kinase domain
Serine/threonine-protein kinase, Sbk1

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SBK1 as an antibody target. Whether an autoantibody or antibody against SBK1 could matter depends on whether native SBK1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SBK1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SBK1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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