Seroatlas · Human Serome Atlas

SAYSD1

SAYSvFN domain-containing protein 1

Also known as: C6orf64, FLJ11101, SAYS1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NPB0
Gene: SAYSD1
Ensembl: ENSG00000112167
Chromosome: 6
Canonical length: 183 aa
Protein class: Predicted membrane proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Enables UFM1-modified protein reader activity. Involved in protein quality control for misfolded or incompletely synthesized proteins and rescue of stalled ribosome. Located in intracellular membrane-bounded organelle. Is active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

183 residues, UniProt reviewed canonical sequence.

>Q9NPB0|SAYSD1
     1  MEQRLAEFRA ARKRAGLAAQ PPAASQGAQT PGEKAEAAAT LKAAPGWLKR FLVWKPRPAS
    61  ARAQPGLVQE AAQPQGSTSE TPWNTAIPLP SCWDQSFLTN ITFLKVLLWL VLLGLFVELE
   121  FGLAYFVLSL FYWMYVGTRG PEEKKEGEKS AYSVFNPGCE AIQGTLTAEQ LERELQLRPL
   181  AGR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SAYSD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

testis: 31 nTPM
salivary gland: 7.9 nTPM
liver: 6.8 nTPM
epididymis: 6.6 nTPM
thymus: 6.6 nTPM
pancreas: 6.2 nTPM

Single-cell type

late primary spermatocytes: 428 nCPM
early spermatids: 109 nCPM
early primary spermatocytes: 86 nCPM
late spermatids: 80 nCPM
oocytes: 69 nCPM
parietal cells: 44 nCPM

Immune cell

eosinophil: 23 nTPM
T-reg: 20 nTPM
naive CD4 T-cell: 18 nTPM
naive B-cell: 18 nTPM
naive CD8 T-cell: 16 nTPM
memory B-cell: 16 nTPM

Brain region

white matter: 8.7 nTPM
choroid plexus: 8.5 nTPM
midbrain: 7.1 nTPM
spinal cord: 7.1 nTPM
basal ganglia: 7 nTPM
medulla oblongata: 7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.65
gnomAD pLI: 0
gnomAD missense Z: -0.53
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

UFM1-modified protein reader activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

SAYSvFN domain
SAYSvFN domain-containing protein 1
Uncharacterized conserved domain (SAYSvFN)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SAYSD1 as an antibody target. Whether an autoantibody or antibody against SAYSD1 could matter depends on whether native SAYSD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SAYSD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SAYSD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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