Seroatlas · Human Serome Atlas

SAXO5

Stabilizer of axonemal microtubules 5

Also known as: C19orf45, FLJ35784, SAXO5_HUMAN, TEX45

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NA69
Gene: SAXO5
Ensembl: ENSG00000198723
Chromosome: 19
Canonical length: 505 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mid piece,Principal piece,End piece

OverviewNCBI Gene

No narrative summary is available for SAXO5 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

505 residues, UniProt reviewed canonical sequence.

>Q8NA69|SAXO5
     1  MATGALLPCS RPCPMSRLDF LKASHFSLGP DLRLHEGTMR TTSHRDFAYP AATREPPSLQ
    61  PPPALLFPMD PRWDREERVS EAHRAFPPPS TPPWELLQAQ ARERTLAMQA GNLHLHEDAH
   121  AGIGLSNAHA AYGWPELPAR TRERIRGARL IFDRDSLPPG DRDKLRIPPT THQALFPPHD
   181  ARPQPRAPSC HLGGPNTLKW DYTRQDGTSY QRQFQALPGP PALRCKRASS GVELGDCKIS
   241  YGSTCSEQKQ AYRPQDLPED RYDKAQATAH IHCVNIRPGD GLFRDRTTKA EHFYAREPEP
   301  FVLHHDQTPE SHILKGNWCP GPGSLDTFMQ YFYGQPPPPT QPPSRHVPHE KLQSHVTLGE
   361  PKLLKRFFKT TMGSDYCPSE WRQVQKAPNL HLQQSYLPRG TGEFDFLTMN QKMLKPHRTP
   421  PAPVTEEMLQ RCKYSHMEPP LGGLRFFSTQ YKDEFPFKYQ GPAALRLKNP QEGFVPLGTP
   481  HQRGCREKID PLVPQPPMYL CPSQQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SAXO5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

testis: 19 nTPM
bone marrow: 1.6 nTPM
retina: 1.3 nTPM
skin: 1.2 nTPM
pituitary gland: 1 nTPM
small intestine: 0.7 nTPM

Single-cell type

late spermatids: 644 nCPM
early spermatids: 256 nCPM
late primary spermatocytes: 65 nCPM
rod photoreceptor cells: 12 nCPM
endometrial luminal cells: 9.4 nCPM
thymocytes: 9.3 nCPM

Immune cell

basophil: 0.6 nTPM
naive B-cell: 0.2 nTPM
neutrophil: 0.2 nTPM
gdT-cell: 0.1 nTPM
intermediate monocyte: 0.1 nTPM
MAIT T-cell: 0.1 nTPM

Brain region

white matter: 9 nTPM
cerebral cortex: 7.4 nTPM
pons: 7.1 nTPM
thalamus: 6.8 nTPM
hypothalamus: 6.7 nTPM
basal ganglia: 6.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.78
gnomAD pLI: 0
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Stabilizer of axonemal microtubules 5
Stabilizer of axonemal microtubules 5

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SAXO5 as an antibody target. Whether an autoantibody or antibody against SAXO5 could matter depends on whether native SAXO5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SAXO5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SAXO5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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