Seroatlas · Human Serome Atlas

SAXO4

Stabilizer of axonemal microtubules 4

Also known as: C11orf66, FLJ32771, IIIG9, PPP1R32, SAXO4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z5V6
Gene: SAXO4
Ensembl: ENSG00000162148
Chromosome: 11
Canonical length: 425 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane,Cytosol,Mid piece,Principal piece,End piece

OverviewNCBI Gene

Enables phosphatase binding activity. Predicted to be involved in flagellated sperm motility. Located in ciliary basal body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

425 residues, UniProt reviewed canonical sequence.

>Q7Z5V6|SAXO4
     1  MMGKLPLGVV SPYVKMSSGG YTDPLKFYAT SYCTAYGRED FKPRVGSHVG TGYKSNFQPV
    61  VSCQASLEAL DNPARGEQAQ DHFQSVASQS YRPLEVPDGK HPLPWSMRQT SSGYGREKPS
   121  AGPPTKEVRK VHFDTQEHGP QAITGLEPRE VPLLHQQQGQ DPLERENFRH GPRFMTSEYN
   181  SKYLRDPLDQ PDFLQKKSIG AKEGSGFTKQ SHQSPIVFQP PSQALPGDPA LLPGQSVTKS
   241  DFLPKTHLHG DEFLPVLARG SKRETAFSRG NERILNPRVP PPCPEPSSVS HQQFQPLHRM
   301  QQTNVALLGR ETVGKKEPTG FSLNNPMYVR SPCDPDRDQR YLTTYNQGYF ENIPKGLDQE
   361  GWTRGGIQPQ MPGGYALSQP VSCMEATPNP MESLRHLHPH VGRTLTSADP FYQNTPHSSR
   421  CVAHS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SAXO4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 91 nTPM

Expression across tissuesHPA

Tissue

testis: 91 nTPM
choroid plexus: 51 nTPM
fallopian tube: 38 nTPM
basal ganglia: 16 nTPM
hippocampal formation: 15 nTPM
pituitary gland: 14 nTPM

Single-cell type

late spermatids: 626 nCPM
early spermatids: 273 nCPM
late primary spermatocytes: 108 nCPM
respiratory ciliated cells: 102 nCPM
ependymal cells: 86 nCPM
fallopian tube ciliated cells: 63 nCPM

Immune cell

neutrophil: 2 nTPM
basophil: 1.5 nTPM
intermediate monocyte: 1.3 nTPM
naive CD8 T-cell: 1.3 nTPM
classical monocyte: 1.1 nTPM
gdT-cell: 1 nTPM

Brain region

midbrain: 61 nTPM
choroid plexus: 52 nTPM
medulla oblongata: 44 nTPM
spinal cord: 35 nTPM
pons: 34 nTPM
white matter: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.27
gnomAD pLI: 0
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

flagellated sperm motility

Molecular functions

phosphatase binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Stabilizer of axonemal microtubules 4
Protein phosphatase 1 regulatory subunit 32

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SAXO4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PPP1CA

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SAXO4 as an antibody target. Whether an autoantibody or antibody against SAXO4 could matter depends on whether native SAXO4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SAXO4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SAXO4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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