Seroatlas · Human Serome Atlas

SAXO3

Stabilizer of axonemal microtubules 3

Also known as: SAXO3_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1B0GTJ6
Gene
SAXO3
Canonical length
334 aa

OverviewNCBI Gene

No narrative summary is available for SAXO3 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

334 residues, UniProt reviewed canonical sequence.

>A0A1B0GTJ6|SAXO3
     1  MASGTLAPGC RISATEVPGS RPNCHLTSSY FSHRIIPPIP FTPPTVQSTV ADPLPQVAKQ
    61  DSHNWAFDEV LSRWETTSGS AYVPKTHGGP CAQPRAPEPA DPTRTVGIKD LGEKLRHRGW
   121  RLPLTTKYQS SETRAQYTGS PSGDPRAPEY FGPQPPQLAD HHRGGPSQAL IAWTKNPELS
   181  GRPFTVSDRG VLDRRQLYLT TSARDFRFYP KTELSGYPRK DSLTYWSFEE TPQVWSHGPQ
   241  RPPCPRSSRP PRPPRVRVPR VSPVTSAMPH RGALSLAQES YSPLLHPLRR LDRFCPLEAP
   301  WGGPHWKPLR GIYSVPKAYS TENSSYGSLK PALV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SAXO3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.64

Protein domainsUniProt · Pfam · InterPro

  • Stabilizer of axonemal microtubules 3

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SAXO3 as an antibody target. Whether an autoantibody or antibody against SAXO3 could matter depends on whether native SAXO3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SAXO3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SAXO3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SAXO3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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