Seroatlas · Human Serome Atlas

SAXO2

Stabilizer of axonemal microtubules 2

Also known as: DKFZp666G057, FAM154B, SAXO2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q658L1
Gene: SAXO2
Ensembl: ENSG00000188659
Chromosome: 15
Canonical length: 398 aa
Protein class: Predicted intracellular proteins
Subcellular location: Centrosome,Cytosol,Connecting piece,Mid piece

OverviewNCBI Gene

Predicted to enable microtubule binding activity. Predicted to be active in microtubule cytoskeleton; nucleus; and sperm flagellum. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

398 residues, UniProt reviewed canonical sequence.

>Q658L1|SAXO2
     1  MGAKSMRSWC LCQICSCGSD YCPYEIVKQP RHVPEEYKPK QGKIDLGTTY KRDLNSYKVQ
    61  PVAIVRPLER QVKKGKLDTV PTYKDDYRAW DLHKSELYKP EQTYHPPTVK FGNSTTFQDD
   121  FVPQEIKPRQ SFKPSSVVKR STAPFNGITS HRLDYIPHQL ELKFERPKEV YKPTDQRFED
   181  LTTHRCDFQG LIGETAKLCR PVHTRVTQNA LFEGSTEFRE SFQPWEIPPP EVKKVPEYVP
   241  PTGSMLLNST SHLDYVPYQA NHVVPIRPVS QKRSNNFPFQ GKSIMKEDFP AWESCRQGLI
   301  KKQQQIPNPS GKFDGLSTFR SHYVPHELIP TESCKPLNIA FKSSVPFDDV TMYSVEYTPK
   361  RQEICPASYP SPPGYIFDNT NSQGHKFFRK IIPAVKAF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SAXO2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 48 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 48 nTPM
testis: 19 nTPM
epididymis: 17 nTPM
choroid plexus: 6.7 nTPM
lung: 6.1 nTPM
retina: 5.7 nTPM

Single-cell type

respiratory ciliated cells: 639 nCPM
fallopian tube ciliated cells: 293 nCPM
late spermatids: 259 nCPM
late primary spermatocytes: 121 nCPM
ependymal cells: 121 nCPM
endometrial ciliated cells: 117 nCPM

Immune cell

naive B-cell: 3.2 nTPM
eosinophil: 2.9 nTPM
NK-cell: 1.9 nTPM
memory CD8 T-cell: 1.5 nTPM
memory B-cell: 1.2 nTPM
naive CD4 T-cell: 0.9 nTPM

Brain region

choroid plexus: 20 nTPM
midbrain: 14 nTPM
white matter: 12 nTPM
spinal cord: 9.9 nTPM
medulla oblongata: 9.7 nTPM
cerebral cortex: 9.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.81
gnomAD pLI: 0
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

microtubule binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SAXO2 as an antibody target. Whether an autoantibody or antibody against SAXO2 could matter depends on whether native SAXO2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SAXO2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SAXO2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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