Seroatlas · Human Serome Atlas

SAXO1

Stabilizer of axonemal microtubules 1

Also known as: C9orf138, FAM154A, MGC35182, SAXO1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IYX7
Gene: SAXO1
Ensembl: ENSG00000155875
Chromosome: 9
Canonical length: 474 aa
Protein class: Predicted intracellular proteins
Subcellular location: Flagellar centriole,Mid piece,End piece

OverviewNCBI Gene

Enables microtubule binding activity. Involved in several processes, including cold acclimation; positive regulation of cilium assembly; and protein stabilization. Located in microtubule cytoskeleton and sperm flagellum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

474 residues, UniProt reviewed canonical sequence.

>Q8IYX7|SAXO1
     1  MKTKCICELC SCGRHHCPHL PTKIYDKTEK PCLLSEYTEN YPFYHSYLPR ESFKPRREYQ
    61  KGPIPMEGLT TSRRDFGPHK VAPVKVHQYD QFVPSEENMD LLTTYKKDYN PYPVCRVDPI
   121  KPRDSKYPCS DKMECLPTYK ADYLPWNQPR REPLRLEHKY QPASVRFDNR TTHQDDYPIK
   181  GLVKTISCKP LAMPKLCNIP LEDVTNYKMS YVAHPVEKRF VHEAEKFRPC EIPFESLTTQ
   241  KQSYRGLMGE PAKSLKPLAR PPGLDMPFCN TTEFRDKYQA WPMPRMFSKA PITYVPPEDR
   301  MDLLTTVQAH YTCPKGAPAQ SCRPALQIKK CGRFEGSSTT KDDYKQWSSM RTEPVKPVPQ
   361  LDLPTEPLDC LTTTRAHYVP HLPINTKSCK PHWSGPRGNV PVESQTTYTI SFTPKEMGRC
   421  LASYPEPPGY TFEEVDALGH RIYKPVSQAG SQQSSHLSVD DSENPNQREL EVLA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SAXO1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 36 nTPM

Expression across tissuesHPA

Tissue

testis: 36 nTPM
epididymis: 0.3 nTPM
seminal vesicle: 0.3 nTPM
fallopian tube: 0.2 nTPM
pancreas: 0.2 nTPM
retina: 0.2 nTPM

Single-cell type

early spermatids: 886 nCPM
late primary spermatocytes: 238 nCPM
late spermatids: 91 nCPM
ependymal cells: 85 nCPM
bergmann glia: 52 nCPM
fibro-adipogenic progenitors: 41 nCPM

Immune cell

naive CD8 T-cell: 0.3 nTPM
gdT-cell: 0.1 nTPM
MAIT T-cell: 0.1 nTPM
memory CD8 T-cell: 0.1 nTPM
naive CD4 T-cell: 0.1 nTPM
basophil: 0 nTPM

Brain region

medulla oblongata: 2.1 nTPM
midbrain: 2 nTPM
thalamus: 2 nTPM
spinal cord: 1.7 nTPM
white matter: 1.7 nTPM
cerebral cortex: 1.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.85
gnomAD pLI: 0
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

microtubule binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SAXO1 as an antibody target. Whether an autoantibody or antibody against SAXO1 could matter depends on whether native SAXO1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SAXO1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SAXO1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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