Seroatlas · Human Serome Atlas

SAPCD1

Suppressor APC domain-containing protein 1

Also known as: C6orf26, NG23, SAPC1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5SSQ6
Gene
SAPCD1
Ensembl
ENSG00000228727
Chromosome
6
Canonical length
148 aa
Protein class
Metabolic proteins, Predicted intracellular proteins
Subcellular location
Vesicles,Cell Junctions

OverviewNCBI Gene

No narrative summary is available for SAPCD1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

148 residues, UniProt reviewed canonical sequence.

>Q5SSQ6|SAPCD1
     1  MGSQGSGGVP LVQAPYTVLL LPLGTSRQDP GAQSFFLWLR RMQALEREQD ALWQGLELLQ
    61  HGQAWFEDHL REAQRQQLHL GALGENFLTD LHSEPGRPPL AQIQKVNICL QNLIHEKELS
   121  RQQKGVTQPK EEMAQRGCTK GPRGPTRV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SAPCD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
28 nTPM

Expression across tissuesHPA

Tissue

  • skin: 28 nTPM
  • kidney: 7.5 nTPM
  • pituitary gland: 6.1 nTPM
  • prostate: 6.1 nTPM
  • retina: 6 nTPM
  • spleen: 5.1 nTPM

Single-cell type

  • ependymal cells: 11 nCPM
  • astrocytes: 7.2 nCPM
  • microglia: 4.5 nCPM
  • bergmann glia: 3.1 nCPM
  • choroid plexus epithelial cells: 2.4 nCPM
  • oligodendrocyte progenitor cells: 1.7 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • midbrain: 1.8 nTPM
  • thalamus: 1.8 nTPM
  • choroid plexus: 1.6 nTPM
  • cerebral cortex: 1.5 nTPM
  • medulla oblongata: 1.4 nTPM
  • white matter: 1.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.73
gnomAD pLI
0
gnomAD missense Z
0.28
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SAPCD1 as an antibody target. Whether an autoantibody or antibody against SAPCD1 could matter depends on whether native SAPCD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SAPCD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SAPCD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SAPCD1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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